Influence of loop electrosurgical excision procedure on subsequent acquisition of new human papillomavirus infections.
Influence of loop electrosurgical excision procedure on subsequent acquisition of new human papillomavirus infections.
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DOI：
10.1086/598981
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发表时间：
2009-06-01
期刊：
影响因子：
--
通讯作者：
Schiffman M
中科院分区：
文献类型：
--
作者：
Castle PE;Kreimer AR;Wacholder S;Wheeler CM;Koutsky LA;Rydzak G;Buckman DW;Graubard B;Schiffman M
子宫颈电环切除术（LEEP）治疗宫颈癌前病变对随后获得新的人乳头瘤病毒（HPV）感染的影响尚未得到很好的描述。计算了随访6个月和24个月时治疗与未治疗女性的累积发病率比（IRR）及其95%置信区间（95%CI），包括单个HPV基因型、任何HPV基因型、任何致癌HPV基因型、任何非致癌HPV基因型、比较195例接受阴道镜检查并接受LEEP治疗的HPV阳性妇女与未接受治疗的HPV阳性妇女的HPV基因型和系统发育组（n = 1，625）在进入为期两年的研究时。在6个月的随访中，接受治疗的女性获得致癌HPV基因型的可能性比未接受治疗的女性低29%（IRR = 0.71; 95%CI = 0.50-1.00），在24个月的随访中，接受治疗的女性获得致癌HPV基因型的可能性比未接受治疗的女性低18%（IRR = 0.82，95%CI = 0.68-1.01）。在6个月（IRR = 0.44，95%CI = 0.23-0.85）和24个月（IRR = 0.60，95%CI = 0.42-0.85）时，接受治疗的女性获得α9系统发育物种（包括HPV 16）的HPV基因型的可能性分别降低了56%和40%。LEEP可能会减少某些与HPV 16相关的致癌HPV基因型的获得。
The impact of loop electrosurgical excision procedure (LEEP) treatment for cervical precancerous lesions on subsequent acquisition of new human papillomavirus (HPV) infections is not well described. Cumulative incidence rate ratios (IRR) for treated versus untreated women at 6- and 24-months of follow-up with 95% confidence intervals (95%CI) were calculated for infection by individual HPV genotypes, any HPV genotype, any carcinogenic HPV genotype, any non-carcinogenic HPV genotypes, and phylogenetic groups of HPV genotypes were compared between HPV-positive women who underwent colposcopy and were treated by LEEP (n = 195) and were untreated (n = 1,625) at entry into a two-year study. Treated women were 29% less likely than untreated women to acquire carcinogenic HPV genotypes at the 6-month follow-up (IRR = 0.71; 95%CI = 0.50–1.00) and 18% less likely at the 24-month follow-up (IRR = 0.82, 95%CI = 0.68–1.01). Treated women were, respectively, 56% and 40% less likely to acquire HPV genotypes of the α9 phylogenetic species (which includes HPV16) at 6-months (IRR = 0.44, 95%CI = 0.23–0.85) and 24-months (IRR = 0.60, 95%CI = 0.42–0.85). LEEP may reduce the acquisition of certain carcinogenic HPV genotypes related to HPV16.
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影响因子：
51.1
作者：
Cogliano, V;Baan, R;El Ghissassi, F
通讯作者：
El Ghissassi, F
影响因子：
3.5
作者：
Schiffman, M;Wheeler, CM;Castle, PE
通讯作者：
Castle, PE
DOI：
10.1111/j.1525-1438.2007.00945.x
发表时间：
2007-11-01
影响因子：
4.8
作者：
Bae, J. H.;Kim, C. J.;Park, J. S.
通讯作者：
Park, J. S.
影响因子：
11.2
作者：
Castle, PE;Jeronimo, J;Burk, RD
通讯作者：
Burk, RD
影响因子：
168.9
作者：
Kyrgiou, M;Koliopoulos, G;Paraskevaidis, E
通讯作者：
Paraskevaidis, E