pH-Sensitive liposome retaining Fe-porphyrin as SOD mimic for novel anticancer drug delivery system
pH-Sensitive liposome retaining Fe-porphyrin as SOD mimic for novel anticancer drug delivery system
复制标题
pH 敏感脂质体保留铁卟啉作为 SOD 模拟物用于新型抗癌药物递送系统
DOI：
--
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
M. Yuasa
中科院分区：
文献类型：
--
作者：
H. Kawakami;Kazue Hiraka;Miho Tamai;A. Horiuchi;A. Ogata;Tomomi Hatsugai;A. Yamaguchi;K. Oyaizu;M. Yuasa
在这篇文章中，一种新的抗癌药物传递系统的设计报告的基础上保留铁卟啉作为超氧化物歧化酶（SOD）模拟物的pH敏感的脂质体。脂质体含有阳离子/阴离子脂质组合，由铁卟啉、L-α-磷脂酰胆碱（DMPC）、二甲基双十四烷基溴化铵（DTDAB）、油酸二钠（OA Na）和吐温-80组成。脂质体的大小约为30 nm。发现脂质体的EC 50值（产生针对细胞的50%致死剂量所需的化合物的有效浓度）显著小于作为对照药物的顺铂的EC 50值，表明脂质体显示出对癌细胞的高细胞毒性。这是由于pH敏感性脂质体迅速对应于内体的酸性环境并且不稳定，并且Fe-卟啉被递送到胞质溶胶中。这一结果表明，O - 2可能是一个有用的目标分子，以诱导癌细胞的选择性死亡和pH敏感的脂质体保留铁卟啉作为SOD模拟物是一类新的抗癌剂。
In this article the novel design of an anticancer drug delivery system is reported based on a pH-sensitive liposome retaining the Fe-porphyrin as a superoxide dismutase(SOD) mimic. The liposomes contained cationic/anionic lipid combinations and were composed of Fe-porphyrin, L-α-phosphatidylcholine (DMPC), dimethylditetradecylammonium bromide (DTDAB), sodispdum oleate (OA Na ), and Tween-80. The size of the liposome was approximately 30 nm. The EC 50 value (the effective concentration of compound required to produce a 50% lethal dose against cells) of the liposome was found to be significantly smaller than that of cisplatin as the control drug, suggesting that the liposome showed a high cytotoxicity toward the cancer cells. This is due to the fact that the pH-sensitive liposome rapidly corresponds to the acidic environments of the endosomes and is unstable, and the Fe-porphyrin is delivered into the cytosol. This result suggests that O - 2 may be useful as a target molecule to induce the selective death of cancer cells and that a pH-sensitive liposome retaining Fe-porphyrin as an SOD mimic is a new class of anticancer agent.
DOI：
10.1073/pnas.94.26.14243
发表时间：
1997-12-23
影响因子：
11.1
作者：
Marla, SS;Lee, J;Groves, JT
通讯作者：
Groves, JT
影响因子：
10.8
作者：
Shi, GF;Guo, WJ;Lee, RJ
通讯作者：
Lee, RJ