Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.
Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.
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脂质，糖尿病和冠心病的基因组关联研究信号的比较分析：心血管生物标志物遗传学协作。
DOI：
10.1093/eurheartj/ehr225
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发表时间：
2012-02
影响因子：
39.3
通讯作者：
Hingorani AD
中科院分区：
文献类型：
--
作者：
Angelakopoulou A;Shah T;Sofat R;Shah S;Berry DJ;Cooper J;Palmen J;Tzoulaki I;Wong A;Jefferis BJ;Maniatis N;Drenos F;Gigante B;Hardy R;Laxton RC;Leander K;Motterle A;Simpson IA;Smeeth L;Thomson A;Verzilli C;Kuh D;Ireland H;Deanfield J;Caulfield M;Wallace C;Samani N;Munroe PB;Lathrop M;Fowkes FG;Marmot M;Whincup PH;Whittaker JC;de Faire U;Kivimaki M;Kumari M;Hypponen E;Power C;Humphries SE;Talmud PJ;Price J;Morris RW;Ye S;Casas JP;Hingorani AD
评价新出现的全基因组关联研究的冠心病（CHD）相关单核苷酸多态性（SNP）与已确定和新出现的危险因素的相关性，以及全基因组关联研究的脂质相关SNP与其他危险因素和CHD事件的相关性。使用两项病例对照研究，三项横断面研究和七项前瞻性研究，涉及多达25000名个体和5794例CHD事件，我们评估了34个全基因组关联研究确定的SNP与CHD风险和16个CHD相关风险因素或生物标志物的关联。Ch9p21 SNPs rs1333049（OR 1.17; 95%置信限1.11-1.24）和rs 10757274（OR 1.17; 1.09-1.26），MIA3 rs17465637（OR 1.10; 1.04-1.15），Ch2q36 rs2943634（OR 1.08; 1.03-1.14），APC rs383830（OR 1.10; 1.02，1.18），MTHFD1L rs6922269（OR 1.10; 1.03，1.16），CXCL 12 rs 501120（OR 1.12; 1.04，1.20）和SMAD 3 rs 17228212（OR 1.11; 1.05，1.17）均与CHD风险相关，但与测量的CHD生物标志物和风险因素无关。在20个血脂相关SNP中，LPL rs 17411031与CHD风险降低（OR 0.91; 0.84-0.97）、载脂蛋白AI和HDL-胆固醇升高以及甘油三酯降低相关。SORT 1 rs 599839与CHD风险（OR 1.20; 1.15-1.26）以及总胆固醇、LDL胆固醇和载脂蛋白B相关。ANGPTL 3 rs 12042319与CHD风险（OR 1.11; 1.03，1.19）、总胆固醇和LDL胆固醇、甘油三酯和白细胞介素-6相关。一些预测CHD事件的SNP似乎涉及目前未被确定或新出现的风险因素索引的途径;其他SNP涉及血脂的变化，包括甘油三酯或HDL-胆固醇以及LDL-胆固醇。SNP与多种风险因素和生物标志物的重叠关联支持这些表型的共同调控点的存在。
To evaluate the associations of emergent genome-wide-association study-derived coronary heart disease (CHD)-associated single nucleotide polymorphisms (SNPs) with established and emerging risk factors, and the association of genome-wide-association study-derived lipid-associated SNPs with other risk factors and CHD events. Using two case–control studies, three cross-sectional, and seven prospective studies with up to 25 000 individuals and 5794 CHD events we evaluated associations of 34 genome-wide-association study-identified SNPs with CHD risk and 16 CHD-associated risk factors or biomarkers. The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11–1.24) and rs10757274 (OR 1.17; 1.09–1.26), MIA3 rs17465637 (OR 1.10; 1.04–1.15), Ch2q36 rs2943634 (OR 1.08; 1.03–1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured. Among the 20 blood lipid-related SNPs, LPL rs17411031 was associated with a lower risk of CHD (OR 0.91; 0.84–0.97), an increase in Apolipoprotein AI and HDL-cholesterol, and reduced triglycerides. SORT1 rs599839 was associated with CHD risk (OR 1.20; 1.15–1.26) as well as total- and LDL-cholesterol, and apolipoprotein B. ANGPTL3 rs12042319 was associated with CHD risk (OR 1.11; 1.03, 1.19), total- and LDL-cholesterol, triglycerides, and interleukin-6. Several SNPs predicting CHD events appear to involve pathways not currently indexed by the established or emerging risk factors; others involved changes in blood lipids including triglycerides or HDL-cholesterol as well as LDL-cholesterol. The overlapping association of SNPs with multiple risk factors and biomarkers supports the existence of shared points of regulation for these phenotypes.
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冠状动脉疾病的新遗传基因座的大规模关联分析。
DOI：
10.1161/atvbaha.108.181388
发表时间：
2009-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Coronary Artery Disease Consortium;Samani NJ;Deloukas P;Erdmann J;Hengstenberg C;Kuulasmaa K;McGinnis R;Schunkert H;Soranzo N;Thompson J;Tiret L;Ziegler A
通讯作者：
Ziegler A
影响因子：
15.8
作者：
Danesh, John;Kaptoge, Stephen;Mann, Andrea G.;Sarwar, Nadeem;Wood, Angela;Angleman, Sara B.;Wensley, Frances;Higgins, Julian P. T.;Lennon, Lucy;Eiriksdottir, Gudny;Rumley, Ann;Whincup, Peter H.;Lowe, Gordon D. O.;Gudnason, Vilmundur
通讯作者：
Gudnason, Vilmundur
与人类血液低密度脂蛋白胆固醇、高密度脂蛋白胆固醇或甘油三酯相关的六个新位点。
影响因子：
30.8
作者：
Kathiresan, Sekar;Melander, Olle;Guiducci, Candace;Surti, Aarti;Burtt, Noel P.;Rieder, Mark J.;Cooper, Gregory M.;Roos, Charlotta;Voight, Benjamin F.;Havulinna, Aki S.;Wahlstrand, Bjorn;Hedner, Thomas;Corella, Dolores;Tai, E. Shyong;Ordovas, Jose M.;Berglund, Goran;Vartiainen, Erkki;Jousilahti, Pekka;Hedblad, Bo;Taskinen, Marja-Riitta;Newton-Cheh, Christopher;Salomaa, Veikko;Peltonen, Leena;Groop, Leif;Altshuler, David M.;Orho-Melander, Marju
通讯作者：
Orho-Melander, Marju
影响因子：
7.7
作者：
Freathy RM;Timpson NJ;Lawlor DA;Pouta A;Ben-Shlomo Y;Ruokonen A;Ebrahim S;Shields B;Zeggini E;Weedon MN;Lindgren CM;Lango H;Melzer D;Ferrucci L;Paolisso G;Neville MJ;Karpe F;Palmer CN;Morris AD;Elliott P;Jarvelin MR;Smith GD;McCarthy MI;Hattersley AT;Frayling TM
通讯作者：
Frayling TM
DOI：
10.1056/nejmra0808700
发表时间：
2009-04-23
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hardy J;Singleton A
通讯作者：
Singleton A