Sensitivity to Pulse Phase Duration as a Marker of Neural Health Across Cochlear Implant Recipients and Electrodes.
Sensitivity to Pulse Phase Duration as a Marker of Neural Health Across Cochlear Implant Recipients and Electrodes.
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DOI：
10.1007/s10162-021-00784-5
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Galvin J 3rd
中科院分区：
文献类型：
--
作者：
Zhou N;Zhu Z;Dong L;Galvin J 3rd
在人工耳蜗体中，响度随着脉冲相位持续时间(PPD)的增加比随着脉冲幅度(PA)的增加而增长得更慢，这可能是由于“泄漏”电荷积分所致。这种泄漏最近被量化为“电荷积分效率”，定义为相对于公共阈值锚的PPD动态范围和PA动态范围之间的对数差(两者均以电荷单位表示)。这种泄漏可能在电极和/或测试耳之间有所不同，并可能反映潜在的神经健康状况。在这项研究中，我们研究了接受Cochlear©设备的患者的电荷整合的跨部位差异。PPD和PA的动态范围是相对于具有25或50微秒PPD的两个阈值锚进行测量的。强度-持续时间函数，以前被证明与螺旋神经节细胞和外周突起的存活有关，在选定的电极上与电荷整合效率进行了比较。结果表明，电荷集成效率的跨区域变化与电极位置或阈值水平之间没有显著或系统的关系。50-μS阈值锚的电荷整合效率较低，这表明更大的泄漏与更大的PPD动态范围相关。跨电极的电荷整合效率越差、变化越大，听力损失的持续时间就越长，这与整合不良与神经退化有关的观点是一致的。更多可变的整合效率也与测试耳朵中较差的语音识别性能有关。在最大可接受响度下的强度-持续时间函数的斜率与电荷积分效率显著相关。然而，强度-持续时间斜率不能预测受试者听力损失或语音识别能力的持续时间。因此，电荷集成效率可能是衡量电极阵列上神经种群泄漏程度的更好候选指标，以及人类人工耳蜗术后听神经的总体健康状况。
In cochlear implants, loudness has been shown to grow more slowly with increasing pulse phase duration (PPD) than with pulse amplitude (PA), possibly due to “leaky” charge integration. This leakiness has been recently quantified in terms of “charge integration efficiency,” defined as the log difference between the PPD dynamic range and PA dynamic range (both expressed in charge units), relative to a common threshold anchor. Such leakiness may differ across electrodes and/or test ears, and may reflect underlying neural health. In this study, we examined the across-site variation of charge integration in recipients of Cochlear© devices. PPD and PA dynamic ranges were measured relative to two threshold anchors with either a 25- or 50-microsecond PPD. Strength-duration functions, previously shown to relate to survival of spiral ganglion cells and peripheral processes, were compared to charge integration efficiency on selected electrodes. Results showed no significant or systematic relationship between the across-site variation in charge integration efficiency and electrode position or threshold levels. Charge integration efficiency was poorer with the 50-μs threshold anchor, suggesting that greater leakiness was associated with larger PPD dynamic ranges. Poorer and more variable charge integration efficiency across electrodes was associated with longer duration of any hearing loss, consistent with the idea that poor integration is related to neural degeneration. More variable integration efficiency was also associated with poorer speech recognition performance across test ears. The slopes of the strength-duration functions at maximum acceptable loudness were significantly correlated with charge integration efficiency. However, the strength-duration slopes were not predictive of duration of any hearing loss or speech recognition performance in our participants. As such, charge integration efficiency may be a better candidate to measure leakiness in neural populations across the electrode array, as well as the general health of the auditory nerve in human cochlear implant recipients.
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