Paneth Cells during Viral Infection and Pathogenesis.
Paneth Cells during Viral Infection and Pathogenesis.
复制标题
DOI：
10.3390/v10050225
复制
发表时间：
2018-04-26
期刊：
影响因子：
--
通讯作者：
Smith JG
中科院分区：
文献类型：
--
作者：
Holly MK;Smith JG
Paneth细胞是位于小肠Lieberkühn隐窝的主要分泌细胞。自从一百多年前潘氏细胞被发现以来，我们对潘氏细胞在体内平衡和疾病中扮演的不同角色的理解有了很大的增长。传统上，Paneth细胞一直被描述为抗菌肽和蛋白质的重要来源，这些抗菌肽和蛋白质在宿主防御和塑造共生微生物区系的组成中至关重要。最近，潘氏细胞被证明为隐窝底部的肠道干细胞提供关键的发育和内环境平衡信号。Paneth细胞功能障碍导致的生物失调和受损的上皮屏障与克罗恩病的病因和肠道细菌感染的易感性有关。我们对潘氏细胞对病毒感染的影响的了解是不完整的。由潘氏细胞产生的肠道α-防御素可以直接改变病毒感染。此外，α防御素和其他抗微生物的潘氏细胞产品可能通过影响微生物群间接调节病毒感染。在这里，我们讨论对潘氏细胞生物学的最新见解，研究其功能的模型，以及潘氏细胞对肠道病毒感染的直接和间接影响。
Paneth cells are major secretory cells located in the crypts of Lieberkühn in the small intestine. Our understanding of the diverse roles that Paneth cells play in homeostasis and disease has grown substantially since their discovery over a hundred years ago. Classically, Paneth cells have been characterized as a significant source of antimicrobial peptides and proteins important in host defense and shaping the composition of the commensal microbiota. More recently, Paneth cells have been shown to supply key developmental and homeostatic signals to intestinal stem cells in the crypt base. Paneth cell dysfunction leading to dysbiosis and a compromised epithelial barrier have been implicated in the etiology of Crohn’s disease and susceptibility to enteric bacterial infection. Our understanding of the impact of Paneth cells on viral infection is incomplete. Enteric α-defensins, produced by Paneth cells, can directly alter viral infection. In addition, α-defensins and other antimicrobial Paneth cell products may modulate viral infection indirectly by impacting the microbiome. Here, we discuss recent insights into Paneth cell biology, models to study their function, and the impact, both direct and indirect, of Paneth cells on enteric viral infection.
登录
查看更多内容
影响因子：
5.2
作者：
Adler KB;Tuvim MJ;Dickey BF
通讯作者：
Dickey BF
影响因子：
12.4
作者：
Almohazey, Dana;Lo, Yuan-Hung;Frey, Mark R.
通讯作者：
Frey, Mark R.
影响因子：
4.6
作者：
Andreu, P;Colnot, S;Romagnolo, B
通讯作者：
Romagnolo, B
影响因子：
30.3
作者：
Burger E;Araujo A;López-Yglesias A;Rajala MW;Geng L;Levine B;Hooper LV;Burstein E;Yarovinsky F
通讯作者：
Yarovinsky F
影响因子：
64.8
作者：
Buczacki, Simon J. A.;Zecchini, Heather Ireland;Winton, Douglas J.
通讯作者：
Winton, Douglas J.