Administration schedule for an ethanol-containing diet in pregnancy affects types of offspring brain malformations
Administration schedule for an ethanol-containing diet in pregnancy affects types of offspring brain malformations
复制标题
妊娠期含乙醇饮食的给药方案会影响后代大脑畸形的类型
作者：
H. Sakata;K. Sawada;S. Hisano;Y. Fukui
摘要。在本研究中，我们给怀孕大鼠按不同的时间表饲喂含乙醇的液体饲料，并在妊娠第21天（GD）用免疫组织化学方法检测其幼崽的大脑皮层。第一组妊娠大鼠在妊娠期10-21 （5% Et）饲喂含5% （w/v）乙醇的液体饲料。第二组在GDs 10-12日饲喂含2.5% （w/v）乙醇的液体饲粮，在GDs 13-15日饲喂含4% （w/v）乙醇的饲粮，在GDs 16-21日饲喂含5% （w/v）乙醇的饲粮（2.5-5% Et）。5% Et组幼鼠脑轻脑膜异位主要出现在顶叶皮层。在2.5% - 5%的Et幼崽中，还发现了其他类型的畸形，如沟槽、微回、皮质堆积和第一层缺陷。在第11 ~ 16期，2.5% ~ 5% Et组饲粮采食量和体增重显著高于5% Et组。在GDs 10-21期间，两组之间的总乙醇消耗量没有差异。然而，在2.5% Et组中，GD 15的乙醇消耗量高于5% Et组。怀孕期间不同的含乙醇饮食计划可能会导致大鼠胎儿不同类型的大脑畸形。
Abstract. In the present study, we administered liquid diets containing ethanol to pregnant rats on different schedules, and examined the cerebral cortex of their pups on gestational day (GD) 21 by immunohistochemistry. The first group of pregnant rats was fed a liquid diet containing 5% (w/v) ethanol during GDs 10–21(5% Et). The second group was fed a liquid diet containing 2.5% (w/v) ethanol on GDs 10–12, a diet containing 4% (w/v) ethanol on GDs 13–15, and a diet containing 5% (w/v) ethanol on GDs 16–21 (2.5–5% Et). Pups of 5% Et dams had leptomeningeal heterotopias mainly in the parietal cortex. In 2.5–5% Et pups, other types of malformations such as grooves, microgyri, stacked-up cortices, and defects of layer I were found. The diet intake and body weight gain of 2.5–5% Et dams were significantly higher than those of 5% Et dams during GDs 11–16. There was no difference in total ethanol consumption during GDs 10–21 between the two groups. However, ethanol consumption on GD 15 in 2.5% Et was higher than in 5% Et. A different schedule for administration of an ethanol-containing diet in pregnancy might induce different types of cerebral malformations in rat fetuses.
发育中的小鼠脑壁放射状胶质纤维系统的动态结构。
DOI：
10.1016/0165-3806(89)90126-0
发表时间：
1989
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Gadisseux,JF;Evrard,P;Misson,JP;Caviness,VS
通讯作者：
Caviness,VS
DOI：
10.1111/j.1530-0277.1988.tb01355.x
发表时间：
1988
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Kotkoskie,LA;Norton,S
通讯作者：
Norton,S
影响因子：
56.9
作者：
Ikonomidou, C;Bittigau, P;Olney, JW
通讯作者：
Olney, JW