IL-22: An Underestimated Player in Natural Resistance to Tuberculosis?
IL-22: An Underestimated Player in Natural Resistance to Tuberculosis?
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DOI：
10.3389/fimmu.2018.02209
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发表时间：
2018
影响因子：
7.3
通讯作者：
Cestari M
中科院分区：
文献类型：
--
作者：
Ronacher K;Sinha R;Cestari M
大约10%的潜伏感染结核分枝杆菌（Mtb）的个体在其一生中发展为活动性结核病（TB）。尽管人们普遍认识到t -辅助性1免疫应答对于抑制潜伏性结核感染至关重要，但尚未完全了解赋予结核病进展保护性免疫的全套宿主因子。IL-22由先天免疫系统和适应性免疫系统的细胞产生，包括先天淋巴细胞、自然杀伤细胞以及T淋巴细胞（Th1、Th17和Th22），并与其同源受体IL-22R1结合，IL-22R1在非造血细胞如肺上皮细胞上表达。然而，最近的研究表明，Mtb诱导IL-22R1在感染的巨噬细胞上表达，多项研究表明IL-22在呼吸道感染中具有保护作用。活动性结核病与潜伏性结核病相比，循环IL-22浓度降低，结核病患者与对照组相比，产生mtb特异性IL-22的T细胞百分比降低，这表明该细胞因子在结核病免疫学中起着关键作用。最近，有研究表明，与无合并症的结核病患者相比，2型糖尿病（T2D）和结核病合并症患者血清IL-22浓度进一步降低。然而，低IL-22与结核病易感性增加和结核病疾病严重程度之间是否存在因果关系仍有待确定。本文综述了IL-22在结核自然耐药性中的作用，IL-22在结核免疫反应和肺上皮之间的界面上可能被低估。
Approximately 10% of individuals latently infected with Mycobacterium tuberculosis (Mtb) develop active tuberculosis (TB) during their lifetime. Although it is well recognized that T-helper 1 immune responses are crucial for containing latent TB infection, the full array of host factors conferring protective immunity from TB progression are not completely understood. IL-22 is produced by cells of the innate and adaptive immune system including innate lymphoid cells, and natural killer cells as well as T lymphocytes (Th1, Th17, and Th22) and binds to its cognate receptor, the IL-22R1, which is expressed on non-hematopoietic cells such as lung epithelial cells. However, recent studies suggest that Mtb induces expression of the IL-22R1 on infected macrophages and multiple studies have indicated a protective role of IL-22 in respiratory tract infections. Reduced concentrations of circulating IL-22 in active TB compared to latent TB and decreased percentages of Mtb-specific IL-22 producing T cells in TB patients compared to controls designate this cytokine as a key player in TB immunology. More recently, it has been shown that in type 2 diabetes (T2D) and TB co-morbidity serum IL-22 concentrations are further reduced compared to TB patients without co-morbidities. However, whether a causative link between low IL-22 and increased susceptibility to TB and disease severity of TB exists remains to be established. This review summarizes the contribution of IL-22, a potentially under-appreciated key player in natural resistance to TB, at the interface between the immune response to Mtb and the lung epithelium.
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DOI：
10.1016/j.tube.2011.06.009
发表时间：
2011-11
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
--
作者：
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发表时间：
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影响因子：
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作者：
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DOI：
10.1016/j.tube.2015.06.004
发表时间：
2015-12
期刊：
Tuberculosis (Edinburgh, Scotland)
影响因子：
--
作者：
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通讯作者：
Babu S
影响因子：
4.4
作者：
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通讯作者：
Vankayalapati, Ramakrishna