Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms.
Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms.
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DOI：
10.1007/s11892-012-0302-7
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发表时间：
2012-10
影响因子：
4.2
通讯作者：
Sarras, Michael P., Jr.
中科院分区：
文献类型：
--
作者：
Intine, Robert V.;Sarras, Michael P., Jr.
最近的估计表明，糖尿病目前影响世界人口的百分之十以上。来自实验室和大规模临床试验的证据表明，长期高血糖症诱导慢性并发症，即使在通过代谢记忆现象在药学上实现血糖控制时，这些慢性并发症也持续存在并不受阻碍地进展。表观基因组由所有染色质修饰组成，包括翻译后组蛋白修饰、通过miRNA的表达控制和DNA内胞嘧啶的甲基化。这些表观遗传标记的修饰不仅使细胞和生物体能够对不断变化的环境刺激做出快速反应，而且还赋予细胞“记忆”这些遭遇的能力。因此，这些过程作为代谢记忆和慢性糖尿病并发症的潜在分子机制受到了广泛关注。在这里，我们提出了一个审查最近发表的文献有关这一问题。
Recent estimates indicate that diabetes mellitus currently affects more than ten percent of the world’s population. Evidence from both the laboratory and large scale clinical trials has revealed that prolonged hyperglycemia induces chronic complications which persist and progress unimpeded even when glycemic control is pharmaceutically achieved via the phenomenon of metabolic memory. The epigenome is comprised of all chromatin modifications including post translational histone modification, expression control via miRNAs and the methylation of cytosine within DNA. Modifications of these epigenetic marks not only allow cells and organisms to quickly respond to changing environmental stimuli but also confer the ability of the cell to “memorize” these encounters. As such, these processes have gained much attention as potential molecular mechanisms underlying metabolic memory and chronic diabetic complications. Here we present a review of the very recent literature published pertaining to this subject.
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影响因子：
46.9
作者：
Ball, Madeleine P.;Li, Jin Billy;Gao, Yuan;Lee, Je-Hyuk;LeProust, Emily M.;Park, In-Hyun;Xie, Bin;Daley, George Q.;Church, George M.
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影响因子：
16.2
作者：
Gaede, Peter;Valentine, William J.;Palmer, Andrew J.;Tucker, Daniel M. D.;Lammert, Morten;Parving, Hans-Henrik;Pedersen, Oluf
通讯作者：
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