Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.
Drosophila p38 MAPK interacts with BAG-3/starvin to regulate age-dependent protein homeostasis.
复制标题
DOI：
10.1111/acel.13481
复制
发表时间：
2021-11
期刊：
影响因子：
7.8
通讯作者：
Vrailas-Mortimer AD
中科院分区：
文献类型：
--
作者：
Ryan SM;Almassey M;Burch AM;Ngo G;Martin JM;Myers D;Compton D;Archie S;Cross M;Naeger L;Salzman A;Virola-Iarussi A;Barbee SA;Mortimer NT;Sanyal S;Vrailas-Mortimer AD
随着生物体的老化，它们通常会积累被认为有毒的蛋白质聚集体，可能会导致与年龄相关的疾病。这种蛋白质聚集体的积累部分归因于未能维持蛋白质的动态平衡。多种遗传因素与长寿有关，但这些因素如何也有助于蛋白质动态平衡还不完全清楚。为了了解衰老和蛋白质聚集之间的关系，我们测试了调节寿命和年龄依赖的运动行为的基因p38MAPK(P38Kb)如何随着生物体的衰老影响蛋白质的动态平衡。我们发现，p38Kb通过与肌肉蛋白质稳态调节因子饥饿蛋白的相互作用来调节与年龄相关的蛋白质聚集。此外，我们还发现Lamin是p38Kb和饥饿蛋白的年龄依赖性靶标。我们发现，p38MAPK(P38Kb)通过与Bag蛋白starvin相互作用来调节依赖年龄的蛋白质的动态平衡。此外，我们还发现衰老基因Lamin A/C的同源基因Lamin Dm0是p38Kb和STV在衰老过程中降解的靶标。
As organisms age, they often accumulate protein aggregates that are thought to be toxic, potentially leading to age‐related diseases. This accumulation of protein aggregates is partially attributed to a failure to maintain protein homeostasis. A variety of genetic factors have been linked to longevity, but how these factors also contribute to protein homeostasis is not completely understood. In order to understand the relationship between aging and protein aggregation, we tested how a gene that regulates lifespan and age‐dependent locomotor behaviors, p38 MAPK (p38Kb), influences protein homeostasis as an organism ages. We find that p38Kb regulates age‐dependent protein aggregation through an interaction with starvin, a regulator of muscle protein homeostasis. Furthermore, we have identified Lamin as an age‐dependent target of p38Kb and starvin. We find that p38 MAPK (p38Kb) regulates age‐dependent protein homeostasis through an interaction with the BAG protein, starvin. In addition, we find that Lamin Dm0, a homologue of the aging gene Lamin A/C, is a target of p38Kb and stv for degradation during aging.
登录
查看更多内容
影响因子：
3.3
作者：
Bank EM;Ben-Harush K;Wiesel-Motiuk N;Barkan R;Feinstein N;Lotan O;Medalia O;Gruenbaum Y
通讯作者：
Gruenbaum Y
影响因子：
3.3
作者：
Coulson, M;Robert, S;Saint, R
通讯作者：
Saint, R
影响因子：
11.4
作者：
Barascu, Aurelia;Le Chalony, Catherine;Bertrand, Pascale
通讯作者：
Bertrand, Pascale
影响因子：
4.6
作者：
Dialynas, George;Speese, Sean;Wallrath, Lori L.
通讯作者：
Wallrath, Lori L.
影响因子：
64.8
作者：
Eriksson, M;Brown, WT;Collins, FS
通讯作者：
Collins, FS