SARS-CoV-2 Omicron Symptomatic Infections in Previously Infected or Vaccinated South African Healthcare Workers.
SARS-CoV-2 Omicron Symptomatic Infections in Previously Infected or Vaccinated South African Healthcare Workers.
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DOI：
10.3390/vaccines10030459
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发表时间：
2022-03-17
期刊：
影响因子：
7.8
通讯作者：
On Behalf Of The Wits Vida Hcw Study Group
中科院分区：
文献类型：
--
作者：
Nunes MC;Mbotwe-Sibanda S;Baillie VL;Kwatra G;Aguas R;Madhi SA;On Behalf Of The Wits Vida Hcw Study Group
我们调查了出现SARS-CoV-2感染症状的医护人员（HCW）中的Omicron感染，并评估了疫苗接种或既往感染的保护作用。2021年11月24日至12月31日期间，南非约翰内斯堡的HCW通过核酸扩增测试（NAAT）进行了SARS-CoV-2感染测试。在症状性访视时或之前3个月采集的血液样本进行了加标蛋白免疫球蛋白G（IgG）检测。总体而言，433例有症状的HCW被纳入分析，其中190例（43.9%）感染Omicron; 69例（16.7%）未接种疫苗，270例（62.4%）接受了单剂Ad26.COV.2疫苗。未接种疫苗和Ad26.COV.2接种疫苗的HCW之间识别Omicron的几率没有差异（调整后的比值比（aOR）0.81，95%置信区间（CI）：0.46，1.43）。154例（35.3%）HCW至少有一次经NAAT证实的SARS-CoV-2既往感染;与既往无感染者相比，这些HCW Omicron感染的几率较低（aOR 0.55，95%CI：0.36，0.84）。1549结合抗体单位/mL的抗加标IgG浓度表明症状性Omicron感染的风险显著降低。我们发现HCW中Omicron变异体的再感染率和疫苗突破感染率较高。既往感染和高抗加标IgG浓度对Omicron感染具有保护作用。
We investigated Omicron infections among healthcare workers (HCW) presenting with symptoms of SARS-CoV-2 infection and evaluated the protective effect of vaccination or prior infection. Between 24 November and 31 December 2021, HCW in Johannesburg, South Africa, were tested for SARS-CoV-2 infection by Nucleic Acid Amplification Test (NAAT). Blood samples collected either at the symptomatic visit or in the 3 months prior, were tested for spike protein immunoglobulin G (IgG). Overall, 433 symptomatic HCW were included in the analysis, with 190 (43.9%) having an Omicron infection; 69 (16.7%) were unvaccinated and 270 (62.4%) received a single dose of the Ad26.COV.2 vaccine. There was no difference in the odds of identifying Omicron between unvaccinated and Ad26.COV.2 vaccinated HCW (adjusted odds ratio (aOR) 0.81, 95% confidence interval (CI): 0.46, 1.43). One-hundred and fifty-four (35.3%) HCW had at least one SARS-CoV-2 NAAT-confirmed prior infection; these had lower odds of Omicron infection compared with those without past infection (aOR 0.55, 95%CI: 0.36, 0.84). Anti-spike IgG concentration of 1549 binding antibody unit/mL was suggestive of significant reduction in the risk of symptomatic Omicron infection. We found high reinfection and vaccine breakthrough infection rates with the Omicron variant among HCW. Prior infection and high anti-spike IgG concentration were protective against Omicron infection.
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DOI：
10.3390/v14010079
发表时间：
2022-01-02
期刊：
Viruses
影响因子：
--
作者：
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10.1056/nejmoa2119451
发表时间：
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影响因子：
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DOI：
10.1198/106186006x133933
发表时间：
2006-09-01
影响因子：
2.4
作者：
Hothorn, Torsten;Hornik, Kurt;Zeileis, Achim
通讯作者：
Zeileis, Achim
影响因子：
3.1
作者：
Kwatra G;Nunes M;Dhar N;Baillie V;Serafin N;Jones S;Madhi SA
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