MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.
MicroRNA-132 regulates recognition memory and synaptic plasticity in the perirhinal cortex.
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DOI：
10.1111/j.1460-9568.2012.08220.x
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发表时间：
2012-10
期刊：
影响因子：
--
通讯作者：
Uney JB
中科院分区：
文献类型：
--
作者：
Scott HL;Tamagnini F;Narduzzo KE;Howarth JL;Lee YB;Wong LF;Brown MW;Warburton EC;Bashir ZI;Uney JB
有证据表明，识别记忆的获得依赖于CREB依赖的持久变化，在嗅周皮层突触可塑性。CREB反应性microRNA miR-132已被证明可以调节突触传递，我们着手研究这种microRNA在识别记忆及其潜在可塑性机制中的作用。为此，我们选择性地介导了大鼠嗅周皮质中miR-132的特异性过表达，并证明了短期识别记忆的损伤。这种功能缺陷与长时程抑郁和长时程增强的减少有关。这些结果证实了microRNA是介导大脑中经验依赖性变化的细胞内途径的关键协调者。此外，这些结果证明了miR-132在短期识别记忆形成的神经元机制中的作用。
Evidence suggests that the acquisition of recognition memory depends upon CREB-dependent long-lasting changes in synaptic plasticity in the perirhinal cortex. The CREB-responsive microRNA miR-132 has been shown to regulate synaptic transmission and we set out to investigate a role for this microRNA in recognition memory and its underlying plasticity mechanisms. To this end we mediated the specific overexpression of miR-132 selectively in the rat perirhinal cortex and demonstrated impairment in short-term recognition memory. This functional deficit was associated with a reduction in both long-term depression and long-term potentiation. These results confirm that microRNAs are key coordinators of the intracellular pathways that mediate experience-dependent changes in the brain. In addition, these results demonstrate a role for miR-132 in the neuronal mechanisms underlying the formation of short-term recognition memory.
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DOI：
10.1523/jneurosci.1746-10.2010
发表时间：
2010-09-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fortin DA;Davare MA;Srivastava T;Brady JD;Nygaard S;Derkach VA;Soderling TR
通讯作者：
Soderling TR
影响因子：
25
作者：
Mellios N;Sugihara H;Castro J;Banerjee A;Le C;Kumar A;Crawford B;Strathmann J;Tropea D;Levine SS;Edbauer D;Sur M
通讯作者：
Sur M
影响因子：
16.2
作者：
Edbauer, Dieter;Neilson, Joel R.;Foster, Kelly A.;Wang, Chi-Fong;Seeburg, Daniel P.;Batterton, Matthew N.;Tada, Tomoko;Dolan, Bridget M.;Sharp, Phillip A.;Sheng, Morgan
通讯作者：
Sheng, Morgan
影响因子：
25
作者：
Tognini P;Putignano E;Coatti A;Pizzorusso T
通讯作者：
Pizzorusso T
影响因子：
6.1
作者：
Asaka, Y;Jugloff, DGM;Fitzsimonds, RM
通讯作者：
Fitzsimonds, RM