Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila.
Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila.
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DOI：
10.1016/j.cub.2017.06.004
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发表时间：
2017-07-10
期刊：
影响因子：
--
通讯作者：
Karpac J
中科院分区：
文献类型：
--
作者：
Zhao X;Karpac J
组织间通讯对于控制生物体能量稳态以响应进食和活动或外部挑战的时间变化至关重要。肌肉通过消耗脂质、碳水化合物和氨基酸以及控制全身信号网络，成为这种稳态控制的关键介质。然而，仍然不太清楚能量底物使用组织（例如肌肉）如何与能量底物储存组织通信以适应能量供应和需求的昼夜变化。使用果蝇，我们在这里表明，肌肉在促进脂肪储存组织中脂质的系统合成和积累中起着至关重要的生理作用，从而影响循环脂质水平的昼夜变化。我们的数据显示，代谢转录因子Foxo控制骨骼肌中细胞因子Unpaired 2（Upd 2）的表达，Upd 2作为肌因子控制胰高血糖素样脂肪动力激素（AKH）从专门的神经内分泌细胞分泌。循环AKH水平反过来调节脂肪体/脂肪和肠中的脂质稳态。我们的数据还表明，这种新的肌因子依赖性激素模块是至关重要的，以维持昼夜节律循环脂质。这种组织串扰提供了一种假定的机制，允许肌肉将自主能量需求与系统能量储存和周转相结合。总之，这些发现揭示了肌肉和脂肪储存组织之间的昼夜组织间信号网络，该网络构成了控制全身能量稳态的祖先机制。Zhao和Karpac表明，果蝇肌肉可以系统地控制脂肪体和肠道中的脂质合成。这种组织间通讯由Foxo依赖性肌因子（Upd2）和激素（AKH）信号轴介导，这使得肌肉能够协调昼夜能量需求与储存和合成脂质的组织中的脂肪周转。
Inter-tissue communication is critical to control organismal energy homeostasis in response to temporal changes in feeding and activity or external challenges. Muscle is emerging as a key mediator of this homeostatic control through consumption of lipids, carbohydrates, and amino acids, as well as governing systemic signaling networks. However, it remains less clear how energy substrate usage tissues, such as muscle, communicate with energy substrate storage tissues in order to adapt with diurnal changes in energy supply and demand. Using Drosophila, we show here that muscle plays a crucial physiological role in promoting systemic synthesis and accumulation of lipids in fat storage tissues, which subsequently impacts diurnal changes in circulating lipid levels. Our data reveal that the metabolic transcription factor Foxo governs expression of the cytokine Unpaired 2 (Upd2) in skeletal muscle, which acts as a myokine to control glucagon-like adipokinetic hormone (AKH) secretion from specialized neuroendocrine cells. Circulating AKH levels, in turn, regulate lipid homeostasis in fat body/adipose and the intestine. Our data also reveal that this novel myokine-dependent hormone module is critical to maintain diurnal rhythms in circulating lipids. This tissue cross-talk provides a putative mechanism that allows muscle to integrate autonomous energy demand with systemic energy storage and turnover. Together, these findings reveal a diurnal inter-tissue signaling network between muscle and fat-storage tissues that constitutes an ancestral mechanism governing systemic energy homeostasis. Zhao and Karpac show that Drosophila muscle can systemically control lipid synthesis in fatbody and the intestine. This inter-tissue communication is mediated by a Foxo-dependent myokine (Upd2) and hormonal (AKH) signaling axis, which allows muscle to coordinate diurnal energy demands with fat turnover in tissues that store and synthesize lipids.
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影响因子：
8.1
作者：
Dyar KA;Ciciliot S;Wright LE;Biensø RS;Tagliazucchi GM;Patel VR;Forcato M;Paz MI;Gudiksen A;Solagna F;Albiero M;Moretti I;Eckel-Mahan KL;Baldi P;Sassone-Corsi P;Rizzuto R;Bicciato S;Pilegaard H;Blaauw B;Schiaffino S
通讯作者：
Schiaffino S
影响因子：
9.8
作者：
Grönke S;Müller G;Hirsch J;Fellert S;Andreou A;Haase T;Jäckle H;Kühnlein RP
通讯作者：
Kühnlein RP
影响因子：
10.5
作者：
Amoasii L;Holland W;Sanchez-Ortiz E;Baskin KK;Pearson M;Burgess SC;Nelson BR;Bassel-Duby R;Olson EN
通讯作者：
Olson EN
影响因子：
1.2
作者：
Bach, Erika A.;Ekas, Laura A.;Baeg, Gyeong-Hun
通讯作者：
Baeg, Gyeong-Hun
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS