Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients.
Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients.
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DOI：
10.1155/2020/3764515
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发表时间：
2020
影响因子：
4.6
通讯作者：
Yu L
中科院分区：
文献类型：
--
作者：
Chen D;Sun W;Li J;Wei B;Liu W;Wang X;Song F;Chen L;Yang J;Yu L
本研究旨在确定基线胱抑素 C 水平与 2019 年冠状病毒病 (COVID-19) 之间的关系，并研究血清胱抑素 C 对成年 COVID-19 患者的潜在预后价值。自2020年1月2日起，连续纳入481例COVID-19患者，随访至2020年4月15日。对具有明确结局的COVID-19患者的所有临床和实验室数据进行了审查。对于每项测量，根据血清胱抑素 C 基线水平将 COVID-19 患者分为四分位数。最高的胱抑素 C 水平与 COVID-19 患者更严重的炎症状况、更严重的器官功能障碍和更差的预后显着相关（P 值 < 0.05）。在调整后的逻辑回归分析中，最高的半胱氨酸蛋白酶抑制剂 C 水平和 ln 转化半胱氨酸蛋白酶抑制剂 C 水平与总体患者或无慢性肾病患者中发生危重 COVID-19 和全因死亡的风险独立相关（P 值 < 0.05）。作为一种潜在的炎症标志物，血清胱抑素 C 基线水平的升高可能独立预测 COVID-19 患者的不良后果。住院期间可以常规监测血清胱抑素 C，这对于预测成年 COVID-19 患者的临床意义具有重要意义。
This study aimed at determining the relationship between baseline cystatin C levels and coronavirus disease 2019 (COVID-19) and investigating the potential prognostic value of serum cystatin C in adult patients with COVID-19. 481 patients with COVID-19 were consecutively included in this study from January 2, 2020, and followed up to April 15, 2020. All clinical and laboratory data of COVID-19 patients with definite outcomes were reviewed. For every measure, COVID-19 patients were grouped into quartiles according to the baseline levels of serum cystatin C. The highest cystatin C level was significantly related to more severe inflammatory conditions, worse organ dysfunction, and worse outcomes among patients with COVID-19 (P values < 0.05). In the adjusted logistic regression analyses, the highest cystatin C level and ln-transformed cystatin C levels were independently associated with the risks of developing critically ill COVID-19 and all-cause death either in overall patients or in patients without chronic kidney disease (P values < 0.05). As a potential inflammatory marker, increasing baseline levels of serum cystatin C might independently predict adverse outcomes for COVID-19 patients. Serum cystatin C could be routinely monitored during hospitalization, which showed clinical importance in prognosticating for adult patients with COVID-19.
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影响因子：
158.5
作者：
Li, Qun;Guan, Xuhua;Feng, Zijian
通讯作者：
Feng, Zijian
DOI：
10.15557/pimr.2020.0003
发表时间：
2020-01-01
影响因子：
3.6
作者：
通讯作者：
--
DOI：
10.1080/08998280.2020.1731272
发表时间：
2020-04-01
期刊：
Proceedings (Baylor University. Medical Center)
影响因子：
--
作者：
Columbus, Cristie;Brust, Karen B;Arroliga, Alejandro C
通讯作者：
Arroliga, Alejandro C
影响因子：
19.6
作者：
Cheng, Yichun;Luo, Ran;Xu, Gang
通讯作者：
Xu, Gang
DOI：
10.1164/ajrccm/141.3.698
发表时间：
1990-03-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
CHAPMAN, HA;REILLY, JJ;GRUBB, A
通讯作者：
GRUBB, A