Water-soluble inclusion complexes of trans-polydatin by cyclodextrin complexation: Preparation, characterization and bioactivity evaluation
Water-soluble inclusion complexes of trans-polydatin by cyclodextrin complexation: Preparation, characterization and bioactivity evaluation
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环糊精络合水溶性反式虎杖甙包合物：制备、表征及生物活性评价
DOI：
10.1016/j.molliq.2016.03.054
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发表时间：
2016-07
影响因子：
6
通讯作者：
Jun Lin
中科院分区：
文献类型：
--
作者：
Kun-Ming Jiang;Xiao-Guang Xie;Yi Jin;Jun Lin
制备了反式虎杖苷（PD）与β-CD和γ-CD的包合物。采用UV-vis、ESI-MS、NMR、FT-IR、XRD、SEM、TG和DSC等手段研究了Pd/CD包结物的包结行为、表征及相互作用。所有表征信息均表明PD/CD包合物的形成，并且PD/CD包合物表现出与PD不同的光谱特征和性质。通过ESI-MS实验和Job方法直观地证明了复合物的1：1化学计量比。同时，PD分子的苯环（a环和B环）从较宽的一侧被包含在CD空腔中。PD/CD的水溶性从0.161 mg/mL提高到7.21 mg/mL（PD/β-CD）和12.02 mg/mL（PD/γ-CD）。因此，PD/CD包合物的生物利用度比游离PD有效地提高。本研究提供了有用的信息与PD，一种天然存在的疏水性多酚类化合物草药络合的潜在应用。
The inclusion complexes oftrans-polydatin (PD) with β-CD and γ-CD were prepared. The inclusion complexation behavior, characterization and interactions of PD with CDs were investigated in both the solution and the solid state by means of UV–vis, ESI-MS, NMR, FT-IR, XRD, SEM, TG and DSC. All of the characterization information demonstrated the formation of PD/CDs inclusion complex, and the PD/CDs inclusion complexes exhibited different spectroscopic features and properties from PD. The 1:1 stoichiometry of the complexes was visually proven with the ESI-MS experiment and Job's method. Meanwhile, it was the phenyl group (a and b rings) of the PD molecule that were included in the CDs cavity from the wide side. Moreover, the water solubility of PD/CDs was significantly improved from 0.161 mg/mL to 7.21 mg/mL (PD/β-CD) and 12.02 mg/mL (PD/γ-CD). Consequently, the bioavailability of PD/CDs inclusion complexes were effectively improved over free PD in vitro. The present study provides useful information for the potential application of complexation with PD, a naturally occurring hydrophobic polyphenolic compounds herbal medicine.
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影响因子：
11.2
作者：
Chuan-Fan Xiao;Ke Li;Rong Huang;Guo-Jin He;Jianqiang Zhang;Li Zhu;Qing-Yi Yang;Kunming Jiang;Yi Jin;Jun Lin
通讯作者：
Chuan-Fan Xiao;Ke Li;Rong Huang;Guo-Jin He;Jianqiang Zhang;Li Zhu;Qing-Yi Yang;Kunming Jiang;Yi Jin;Jun Lin
DOI：
10.1007/s10847-013-0315-0
发表时间：
2014
影响因子：
2.3
作者：
Biernacka, Joanna;Betlejewska-Kielak, Katarzyna;Witowska-Jarosz, Janina;Klosinska-Szmurlo, Ewa;Mazurek, Aleksander P.
通讯作者：
Mazurek, Aleksander P.
影响因子：
6.1
作者：
Xingmin Wang;R. Song;Yun-yan Chen;Ming Zhao;K. Zhao
通讯作者：
Xingmin Wang;R. Song;Yun-yan Chen;Ming Zhao;K. Zhao
影响因子：
3.3
作者：
A. Zoppi;Alicia Delrivo;V. Aiassa;M. Longhi
通讯作者：
A. Zoppi;Alicia Delrivo;V. Aiassa;M. Longhi
影响因子：
6.1
作者：
Schulze, K;Schreiber, L;Szankowski, I
通讯作者：
Szankowski, I