Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease.
Association between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease.
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DOI：
10.1186/s12890-018-0686-5
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发表时间：
2018-07-13
影响因子：
3.1
通讯作者：
Hasegawa N
中科院分区：
文献类型：
--
作者：
Yagi K;Asakura T;Namkoong H;Suzuki S;Asami T;Okamori S;Kusumoto T;Funatsu Y;Kamata H;Nishimura T;Ishii M;Betsuyaku T;Hasegawa N
肺鸟分枝杆菌复合群（pMAC）病是一种慢性、缓慢进展的疾病。本研究的目的是确定6分钟步行试验（6 MWT）参数与pMAC疾病患者肺功能和健康相关生活质量（HRQL）的相关性。这项横断面研究包括pMAC成人患者，在庆应义塾大学医院进行。我们研究了6 MWT参数与临床参数的关系，包括肺功能和HRQL，使用36项简明健康调查表（SF-36）和圣乔治呼吸问卷（SGRQ）进行评估。总共有103例连续pMAC患者参加了6 MWT（中位年龄64岁; 80例女性）并完成了SF-36和SGRQ。6分钟步行距离（6 MWD）与所有SGRQ领域得分均呈显著负相关和正相关[ρ = 0.001]。（− 0.54）-（-0.32）]和身体成分总结（PCS）评分（ρ = 0.39）;最终博格量表（FBS）评分则相反（所有SGRQ评分，ρ = 0.34-0.58; PCS评分，ρ =-0.50）。距离-饱和度乘积分别与所有SGRQ评分[ρ =（-0.29）-（-0.55）]和PCS评分（ρ = 0.40）呈显著负相关和正相关。多因素分析显示，6 MWD和FBS评分是HRQL的显著预测因素。我们的研究结果表明，6 MWD和FBS评分是评估pMAC患者HRQL的有用参数。进一步的研究应该调查6 WMT参数对疾病进展、治疗反应和预后的影响。本文的在线版本（10.1186/s12890-018-0686-5）包含补充材料，可供授权用户使用。
Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonary function and the health-related quality of life (HRQL) in patients with pMAC disease. This cross-sectional study included adult patients with pMAC and was conducted at Keio University Hospital. We investigated the relationship of 6MWT parameters with clinical parameters, including pulmonary function, and HRQL, which was assessed using the 36-Item Short Form Health Survey (SF-36) and St. George’s Respiratory Questionnaire (SGRQ). In total, 103 consecutive patients with pMAC participated in 6MWT (median age, 64 years; 80 women) and completed SF-36 and SGRQ. The six-minute walk distance (6MWD) showed significant negative and positive correlations with all SGRQ domain scores [ρ = (− 0.54)–(− 0.32)] and the physical component summary (PCS) score (ρ = 0.39) in SF-36, respectively; the opposite was observed for the final Borg scale (FBS) score (all SGRQ scores, ρ = 0.34–0.58; PCS score, ρ = − 0.50). The distance-saturation product showed significant negative and positive correlations with all SGRQ scores [ρ = (− 0.29)–(− 0.55)] and the PCS score (ρ = 0.40), respectively. Multivariate analysis revealed that 6MWD and the FBS score were significant predictors of HRQL. Our findings suggest that 6MWD and the FBS score are useful parameters for evaluating HRQL in patients with pMAC. Further studies should investigate the impact of 6WMT parameters on disease progression, treatment responses, and prognosis. The online version of this article (10.1186/s12890-018-0686-5) contains supplementary material, which is available to authorized users.
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影响因子：
7.2
作者：
Fukuhara, S;Bito, S;Kurokawa, K
通讯作者：
Kurokawa, K
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
影响因子：
8.3
作者：
Durheim, Michael T.;Smith, Patrick J.;Blumenthal, James A.
通讯作者：
Blumenthal, James A.
影响因子：
10
作者：
MAK, VHF;BUGLER, JR;SPIRO, SG
通讯作者：
SPIRO, SG
影响因子：
4.3
作者：
Lettieri, Christopher J.;Nathan, Steven D.;Shorr, Andrew F.
通讯作者：
Shorr, Andrew F.