Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node.
Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node.
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DOI：
10.1016/j.immuni.2012.11.012
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发表时间：
2013-03-21
期刊：
影响因子：
32.4
通讯作者：
Germain RN
中科院分区：
文献类型：
--
作者：
Kastenmüller W;Brandes M;Wang Z;Herz J;Egen JG;Germain RN
感染后，免疫系统会产生长寿命的记忆淋巴细胞，其频率增加和分化状态改变增强宿主对再次感染的防御。最近，人们发现记忆细胞的空间分布有助于其保护功能。效应记忆 CD8+ T 细胞驻留在最初遇到病原体的外周组织部位，显然是在等待再次感染。在这里，我们发现，在淋巴结 (LN) 内，记忆 CD8+ T 细胞集中在淋巴传播病原体的外周入口附近，促进受感染的前哨巨噬细胞的快速参与。依赖于 CXCL9 的前馈电路提供了额外的趋化信号，进一步增加了局部记忆细胞密度。记忆 CD8+ T 细胞也对局部细胞因子触发物产生效应反应，但它们的动态行为与抗原识别后看到的不同。这些数据揭示了 LN 内幼稚 T 细胞与记忆 T 细胞的不同定位和动态行为，以及这些差异如何促进宿主防御。
After an infection, the immune system generates long-lived memory lymphocytes whose increased frequency and altered state of differentiation enhance host defense against re-infection. Recently, the spatial distribution of memory cells was found to contribute to their protective function. Effector memory CD8+ T cells reside in peripheral tissue sites of initial pathogen encounter, in apparent anticipation of re-infection. Here we show that within lymph nodes (LN), memory CD8+ T cells were concentrated near peripheral entry portals of lymph-borne pathogens, promoting rapid engagement of infected sentinel macrophages. A feed-forward CXCL9-dependent circuit provided additional chemotactic cues that further increase local memory cell density. Memory CD8+ T cells also produced effector responses to local cytokine triggers, but their dynamic behavior differed from that seen following antigen recognition. These data reveal the distinct localization and dynamic behavior of naive vs. memory T cells within LN and how these differences contribute to host defense.
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DOI：
10.1084/jem.20091279
发表时间：
2010-01-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Budhu S;Loike JD;Pandolfi A;Han S;Catalano G;Constantinescu A;Clynes R;Silverstein SC
通讯作者：
Silverstein SC
影响因子：
32.4
作者：
Groom JR;Richmond J;Murooka TT;Sorensen EW;Sung JH;Bankert K;von Andrian UH;Moon JJ;Mempel TR;Luster AD
通讯作者：
Luster AD
影响因子：
64.8
作者：
Jiang, Xiaodong;Clark, Rachael A.;Liu, Luzheng;Wagers, Amy J.;Fuhlbrigge, Robert C.;Kupper, Thomas S.
通讯作者：
Kupper, Thomas S.
影响因子：
30.5
作者：
Henrickson, Sarah E.;Mempel, Thorsten R.;von Andrian, Ulrich H.
通讯作者：
von Andrian, Ulrich H.
影响因子：
4.4
作者：
Katakai, T;Hara, T;Shimizu, A
通讯作者：
Shimizu, A