Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases: Expanding the Therapeutic Approaches by Plant-Derived Natural Products.
Targeting Mitochondrial Dysfunction in Neurodegenerative Diseases: Expanding the Therapeutic Approaches by Plant-Derived Natural Products.
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DOI：
10.3390/ph16020277
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发表时间：
2023-02-13
期刊：
影响因子：
--
通讯作者：
Yuan M
中科院分区：
文献类型：
--
作者：
Zhang X;Wang L;Li B;Shi J;Xu J;Yuan M
Mitochondria are the primary source of energy production in neurons, supporting the high energy consumption of the nervous system. Inefficient and dysfunctional mitochondria in the central nervous system have been implicated in neurodegenerative diseases. Therefore, targeting mitochondria offers a new therapeutic opportunity for neurodegenerative diseases. Many recent studies have proposed that plant-derived natural products, as pleiotropic, safe, and readily obtainable sources of new drugs, potentially treat neurodegenerative diseases by targeting mitochondria. In this review, we summarize recent advances in targeting mitochondria in neurotherapeutics by employing plant-derived natural products. We discuss the mechanism of plant-derived natural products according to their mechanism of action on mitochondria in terms of regulating biogenesis, fusion, fission, bioenergetics, oxidative stress, calcium homeostasis, membrane potential, and mitochondrial DNA stability, as well as repairing damaged mitochondria. In addition, we discuss the potential perspectives and challenges in developing plant-derived natural products to target mitochondria, highlighting the clinical value of phytochemicals as feasible candidates for future neurotherapeutics.
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影响因子：
30.8
作者：
Abrams AJ;Hufnagel RB;Rebelo A;Zanna C;Patel N;Gonzalez MA;Campeanu IJ;Griffin LB;Groenewald S;Strickland AV;Tao F;Speziani F;Abreu L;Schüle R;Caporali L;La Morgia C;Maresca A;Liguori R;Lodi R;Ahmed ZM;Sund KL;Wang X;Krueger LA;Peng Y;Prada CE;Prows CA;Schorry EK;Antonellis A;Zimmerman HH;Abdul-Rahman OA;Yang Y;Downes SM;Prince J;Fontanesi F;Barrientos A;Németh AH;Carelli V;Huang T;Zuchner S;Dallman JE
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Dallman JE
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Lederer WJ
影响因子：
4.3
作者：
Carelli, V;Rugolo, M;Solaini, G
通讯作者：
Solaini, G
DOI：
10.1096/fj.202100067r
发表时间：
2021-06
期刊：
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子：
--
作者：
Adebayo M;Singh S;Singh AP;Dasgupta S
通讯作者：
Dasgupta S
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2.8
作者：
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通讯作者：
Islam, Fakhrul