Smoking and quality of life among female survivors of breast, colorectal and endometrial cancers in a prospective cohort study.
Smoking and quality of life among female survivors of breast, colorectal and endometrial cancers in a prospective cohort study.
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DOI：
10.1007/s11764-010-0147-5
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Lazovich D
中科院分区：
文献类型：
--
作者：
Jang S;Prizment A;Haddad T;Robien K;Lazovich D
研究乳腺癌、结直肠癌或子宫内膜癌幸存者中吸烟与生活质量（QOL）的关系。该研究包括1986年加入爱荷华州妇女健康研究的妇女，随后在2004年被诊断为乳腺癌、结肠直肠癌或子宫内膜癌（n=1920）。在基线和2004年报告吸烟状况; 2004年使用医学结局研究简表-36评估QOL。计算多变量调整的比值比，以检查吸烟状态和不良QOL（评分低于非吸烟者平均值的半个标准差）的相关性。与不吸烟者相比，持续吸烟者报告身体机能不良的可能性更高（比值比[OR] = 2.40，95%置信区间[CI] = 1.32-4.37），心理健康（OR = 1.92，CI = 1.09-3.40），情感角色（OR = 2.01，CI = 1.10-3.66），而既往吸烟者报告身体功能不良的可能性更高（OR = 1.65，CI = 1.10-2.45）、精神健康（OR = 1.62，CI = 1.11-2.37）和一般健康（OR = 1.51，CI = 1.03-2.21）。吸烟组在活力、身体功能、心理健康和情感角色方面观察到生活质量较差的可能性更高的统计学显著趋势。对体力活动的进一步调整导致趋势的比值比和p值衰减。在患有乳腺癌、结直肠癌或子宫内膜癌的女性中，吸烟者比以前或不吸烟者更有可能生活质量较差。在我们的研究中，体力活动部分解释了吸烟状况与生活质量之间的关系。
To examine the association of smoking and quality of life (QOL) among survivors of breast, colorectal, or endometrial cancers. The study included women who joined the Iowa Women’s Health Study in 1986 and were subsequently diagnosed with breast, colorectal, or endometrial cancers through 2004 (n=1920). Smoking status was reported at baseline and in 2004; QOL was assessed in 2004 using the Medical Outcomes Study Short Form-36. Multivariate-adjusted odds ratios were calculated to examine the associations of smoking status and poor QOL (score lower than one-half a standard deviation below the mean of the non-smokers). Compared with non-smokers, persistent smokers had higher likelihood of reporting poor Physical Functioning (odds ratio [OR] = 2.40, 95% confidence interval [CI] = 1.32–4.37), Mental Health (OR = 1.92, CI = 1.09–3.40), and Role Emotional (OR = 2.01, CI = 1.10–3.66), whereas former smokers had higher likelihood of reporting poor Physical Functioning (OR = 1.65, CI = 1.10–2.45), Mental Health (OR = 1.62, CI = 1.11–2.37), and General Health (OR = 1.51, CI = 1.03–2.21). A statistically significant trend toward higher likelihood of poor QOL was observed across smoking groups in Vitality, Physical Functioning, Mental Health, and Role Emotional. Further adjustment for physical activity resulted in attenuation of the odds ratios and p-values for trend. Among women with breast, colorectal, or endometrial cancers, smokers were more likely than former or non-smokers to have poor QOL. Physical activity explained, in part, the association between smoking status and QOL in our study.
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影响因子：
45.3
作者：
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作者：
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