Development of antimalarial drugs and their application in China: a historical review.
Development of antimalarial drugs and their application in China: a historical review.
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DOI：
10.1186/2049-9957-3-9
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发表时间：
2014-03-20
影响因子：
8.1
通讯作者：
Chen C
中科院分区：
文献类型：
--
作者：
Chen C
本文回顾了中国的抗疟疾药物，包括青蒿素、蒿甲醚、青蒿琥酯、双氢青蒿素，以及其他合成药物，如哌喹、咯萘啶、本氟美托、萘酚。特别讨论了这些抗疟药治疗恶性疟疾的疗效，包括氯喹抗性品系。根据世界卫生组织(WHO)推荐的基于青蒿素的联合疗法(ACT)，青蒿素或其衍生物与另一种抗疟疾药物的不同组合被用于口服治疗恶性疟原虫感染。复发率低，配子体携带者减少，治愈率显著提高。联合治疗有效地延缓了寄生虫耐药性的出现。出台《中国抗疟疾药物使用指南及用药方案》，指导合理用药，规范全国疟疾治疗。作为世界推荐的治疗恶性疟疾的一线药物，ACT在条例中被采用。为响应联合国千年发展目标提出的全球根除疟疾倡议，中国政府制定了到2020年消灭疟疾的目标。
This historical review covers antimalarials developed in China, which include artemisinin, artemether, artesunate, and dihydroartemisinin, as well as other synthetic drugs such as piperaquine, pyronaridine, benflumetol (lumefantrine), and naphthoquine. The curative effects of these antimalarials in the treatment of falciparum malaria, including chloroquine-resistant strain, are especially discussed. Following the World Health Organization (WHO) recommended artemisinin-based combination therapy (ACT), different combinations of artemisinin, or its derivative, along with another antimalarial drug were orally used to treat Plasmodium falciparum infections. The recrudescence rates were low, gametocyte carriers lessened, and the curative rate increased remarkably. The combination therapy effectively deferred the emergence of drug resistance in the parasite. The regulation “The guidelines and regimens for the use of antimalarial drugs in China” was issued to guide rational application and standardize malaria treatment in the country. As the recommended first-line drug to treat falciparum malaria in the world, ACT was adopted in the regulation. In response to the global initiative of malaria eradication proposed by the UN Millennium Development Goals (MDGs), the Chinese government has set a target to eliminate malaria by 2020.
DOI：
10.4269/ajtmh.1996.55.223
发表时间：
1996-08-01
影响因子：
3.3
作者：
Kawai, S;Kano, S;Suzuki, M
通讯作者：
Suzuki, M
DOI：
10.1016/s0378-4347(96)00410-0
发表时间：
1997-03-07
期刊：
JOURNAL OF CHROMATOGRAPHY B
影响因子：
--
作者：
Jayaraman, SD;Ismail, S;Navaratnam, V
通讯作者：
Navaratnam, V
DOI：
10.1080/00034983.2000.11813571
发表时间：
2000-07-01
影响因子：
--
作者：
Gogtay, NJ;Kadam, VS;Kshirsagar, NA
通讯作者：
Kshirsagar, NA