Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project.
Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project.
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埃塞俄比亚农村幼儿的弯曲杆菌定植，环境肠功能障碍，发育迟缓和相关危险因素：弯曲杆菌基因组学和环境肠功能障碍（CAIGED）项目的横断面研究。
DOI：
10.3389/fpubh.2020.615793
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发表时间：
2020
影响因子：
5.2
通讯作者：
Havelaar AH
中科院分区：
文献类型：
--
作者：
Chen D;McKune SL;Singh N;Yousuf Hassen J;Gebreyes W;Manary MJ;Bardosh K;Yang Y;Diaz N;Mohammed A;Terefe Y;Roba KT;Ketema M;Ameha N;Assefa N;Rajashekara G;Deblais L;Ghanem M;Yimer G;Havelaar AH
畜牧业提供了一种可能的机制，小农可以通过这种机制满足其家庭对动物源食品的需求，这可能会降低发育迟缓的风险。然而，与家畜的直接/间接接触可能增加弯曲杆菌属的定殖，其与环境性肠功能障碍（EED）和发育迟缓有关。在埃塞俄比亚东部农村进行了一项横断面研究，涉及102名随机选择的12至16个月大的儿童，以确定弯曲杆菌定植、EED和发育迟缓的患病率，并评估潜在的风险因素。数据收集于2018年9月至12月期间。EED和发育迟缓的患病率分别为50%（95% CI：40-60%）和41%（95% CI：32-51%）。在登记的儿童中，56%在过去24小时内食用了一些ASF; 47%在过去15天内腹泻，50%发烧。54、63、71或43%的家庭拥有至少一只鸡、牛/公牛、山羊或绵羊; 54（53%）户在室内过夜饲养鸡，其中只有一半限制动物。卫生条件很差，大量厕所未经改善，露天排便。大多数家庭都能获得经改善的饮用水源。通过PCR，弯曲杆菌定植的患病率为50%（95%CI：41-60%）。除了耐热性菌种空肠弯曲菌、结肠弯曲菌和乌普萨拉弯曲菌外，与猪弯曲菌和胎儿弯曲菌相关的非耐热性菌种也经常通过荟萃总RNA测序（MetTRS）检测到。目前的母乳喂养和ASF消费增加了PCR检测弯曲杆菌的几率，而改善饮用水供应则降低了EED的几率。没有风险因素与发育迟缓显著相关。进一步的研究是必要的，以更好地了解水库和传播途径的弯曲杆菌属。及其对儿童健康的潜在影响。
Livestock farming provides a possible mechanism by which smallholder farmers can meet their household need for animal source foods (ASF), which may reduce the risk of stunting. However, direct/indirect contacts with domestic animals may increase colonization by Campylobacter spp., which has been associated with Environmental Enteric Dysfunction (EED) and stunting. A cross-sectional study involving 102 randomly selected children between 12 and 16 months of age was conducted in rural eastern Ethiopia to establish prevalence rates of Campylobacter colonization, EED, and stunting, and evaluate potential risk factors. Data were collected between September and December 2018. The prevalence of EED and stunting was 50% (95% CI: 40–60%) and 41% (95% CI: 32–51%), respectively. Among enrolled children, 56% had consumed some ASF in the previous 24 h; 47% had diarrhea and 50% had fever in the past 15 days. 54, 63, 71 or 43% of households owned at least one chicken, cow/bull, goat, or sheep; 54 (53%) households kept chickens indoors overnight and only half of these confined the animals. Sanitation was poor, with high levels of unimproved latrines and open defecation. Most households had access to an improved source of drinking water. The prevalence of Campylobacter colonization was 50% (95% CI: 41–60%) by PCR. In addition to the thermotolerant species Campylobacter jejuni, Campylobacter coli and Campylobacter upsaliensis, non-thermotolerant species related to Campylobacter hyointestinalis and Campylobacter fetus were frequently detected by Meta-total RNA sequencing (MeTRS). Current breastfeeding and ASF consumption increased the odds of Campylobacter detection by PCR, while improved drinking water supply decreased the odds of EED. No risk factors were significantly associated with stunting. Further studies are necessary to better understand reservoirs and transmission pathways of Campylobacter spp. and their potential impact on child health.
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影响因子：
15.8
作者：
Havelaar AH;Kirk MD;Torgerson PR;Gibb HJ;Hald T;Lake RJ;Praet N;Bellinger DC;de Silva NR;Gargouri N;Speybroeck N;Cawthorne A;Mathers C;Stein C;Angulo FJ;Devleesschauwer B;World Health Organization Foodborne Disease Burden Epidemiology Reference Group
通讯作者：
World Health Organization Foodborne Disease Burden Epidemiology Reference Group
DOI：
10.1093/cid/ciw542
发表时间：
2016-11-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Amour C;Gratz J;Mduma E;Svensen E;Rogawski ET;McGrath M;Seidman JC;McCormick BJ;Shrestha S;Samie A;Mahfuz M;Qureshi S;Hotwani A;Babji S;Trigoso DR;Lima AA;Bodhidatta L;Bessong P;Ahmed T;Shakoor S;Kang G;Kosek M;Guerrant RL;Lang D;Gottlieb M;Houpt ER;Platts-Mills JA;Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators
通讯作者：
Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) Network Investigators
影响因子：
3.2
作者：
通讯作者：
--
影响因子：
6.7
作者：
Giallourou N;Medlock GL;Bolick DT;Medeiros PH;Ledwaba SE;Kolling GL;Tung K;Guerry P;Swann JR;Guerrant RL
通讯作者：
Guerrant RL
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo