Function and regulation of F-box/WD repeat-containing protein 7
Function and regulation of F-box/WD repeat-containing protein 7
复制标题
F-box/WD重复序列蛋白7的功能和调控
DOI：
10.3892/ol.2020.11728
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发表时间：
2020-06
期刊：
影响因子：
2.9
通讯作者：
Shunrong Ji
中科院分区：
文献类型：
--
作者：
Zheng Zhang;Qiangsheng Hu;Wenyan Xu;Wensheng Liu;Mengqi Liu;Qiqing Sun;Zeng Ye;Guixiong Fan;Yi Qin;Xiaowu Xu;Xianjun Yu;Shunrong Ji
泛素-蛋白酶体系统是一个重要的翻译后修饰系统，参与细胞周期调控、基因转录、信号转导、凋亡、分化和发育等生物学过程。F-box/WD repeat-containing protein 7（F-box/WD repeat-containing protein 7，FBXW 7）是研究最多的F-box（FBX）蛋白之一，是S期激酶相关蛋白1-Cullin 1-FBX蛋白复合物的底物识别组分。作为一种肿瘤抑制因子，FBXW 7识别许多原癌蛋白，并促进其泛素化和随后的蛋白酶体降解。FBXW 7在不同水平上受到调节，导致对其底物的活性和丰度的可调和特异性控制。因此，基因突变或其表达的减少在肿瘤发展中起重要的生物学作用。FBXW 7靶向的其他底物的深入研究和鉴定表明FBXW 7调节的信号网络，包括其肿瘤抑制作用。本文就FBXW 7在肿瘤抑制中的作用及其在肿瘤治疗中的应用作一综述。
The ubiquitin-proteasome system is an important post-translational modification system involved in numerous biological processes, such as cell cycle regulation, gene transcription, signal transduction, apoptosis, differentiation and development. F-box/WD repeat-containing protein 7 (FBXW7) is one of the most studied F-box (FBX) proteins, serving as substrate recognition component of S phase kinase-associated protein 1-Cullin 1-FBX protein complexes. As a tumor suppressor, FBXW7 recognizes numerous proto-oncoproteins and promotes their ubiquitination and subsequent proteasomal degradation. FBXW7 is regulated at different levels, leading to tunable and specific control of the activity and abundance of its substrates. Therefore, genetic mutations or decreases in its expression serve an important biological role in tumor development. In-depth studies and identification of additional substrates targeted by FBXW7 have suggested a signaling network regulated by FBXW7, including its tumor-inhibitory role. The present review focused on the role of FBXW7 in tumor suppression and its application in cancer therapy.
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