Regulation of inflammation and T cells by glycogen synthase kinase-3: links to mood disorders.
Regulation of inflammation and T cells by glycogen synthase kinase-3: links to mood disorders.
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DOI：
10.1159/000356550
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发表时间：
2014
影响因子：
2.4
通讯作者：
Beurel E
中科院分区：
文献类型：
--
作者：
Beurel E
大量的证据表明，免疫系统在调节抑郁症的易感性方面发挥了作用。促炎细胞因子已被证明参与促进人类和小鼠抑郁行为的诱导，为治疗干预开辟了新的途径。由于糖原合成酶激酶-3（GSK 3）最近被发现控制促炎细胞因子的产生，并且多年来GSK 3被认为与情绪障碍有关，因此已经提出GSK 3的促炎作用可能有助于促进对抑郁行为的易感性。此外，除了调节细胞因子的产生外，GSK 3还促进Th细胞的促炎亚型的分化，这足以诱导小鼠的抑郁行为。尽管免疫系统在抑郁行为中的明确参与仍然需要得到有力的证明，但越来越多的证据表明炎症参与了抑郁行为的诱导。
Substantial evidence has implicated a role for the immune system in regulating the susceptibility to depression. Proinflammatory cytokines have been shown to be involved in promoting the induction of depressive behavior both in humans and mice, opening new avenues for therapeutic intervention. Because glycogen synthase kinase-3 (GSK3) was recently found to control the production of proinflammatory cytokines, and for many years GSK3 has been implicated in mood disorders, it has been proposed that the proinflammatory action of GSK3 may contribute to the promoting susceptibility to depressive behavior. Moreover, besides regulating cytokine production, GSK3 also promotes the differentiation of proinflammatory subtypes of Th cells, which are sufficient to induce depressive behavior in mice. Although the clear involvement of the immune system during depressive behavior still needs to be firmly demonstrated, there is growing evidence for the involvement of inflammation in the induction of depressive behavior.
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影响因子：
10.6
作者：
Miller, Andrew H.;Maletic, Vladimir;Raison, Charles L.
通讯作者：
Raison, Charles L.
影响因子：
7.6
作者：
Li, XH;Zhu, W;Jope, RS
通讯作者：
Jope, RS
DOI：
10.4049/jimmunol.1003511
发表时间：
2011-02-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Beurel E;Yeh WI;Michalek SM;Harrington LE;Jope RS
通讯作者：
Jope RS
影响因子：
16.8
作者：
Beurel E;Michalek SM;Jope RS
通讯作者：
Jope RS
影响因子：
4.7
作者：
Mai, L;Jope, RS;Li, XH
通讯作者：
Li, XH