Encoding of mixtures in a simple olfactory system.
Encoding of mixtures in a simple olfactory system.
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DOI:
10.1016/j.neuron.2013.08.026
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发表时间:
2013-12-04
期刊:
影响因子:
16.2
通讯作者:
Laurent G
中科院分区:
文献类型:
--
作者:
Shen K;Tootoonian S;Laurent G
Natural odors are usually mixtures; yet humans and animals can experience them as unitary percepts. Olfaction also enables stimulus categorization and generalization. We addressed how these computations are performed with the responses of 168 locust antennal lobe projection neurons (PNs) to varying mixtures of two monomolecular odors, and 174 PNs and 209 mushroom body Kenyon cells (KCs) to mixtures of up to 8 monomolecular odors. Single PN responses showed strong hypo-additivity, and population trajectories clustered by odor concentration and mixture similarity. KC responses were much sparser on average than with PNs and often signaled the presence of single components in mixtures. Linear classifiers could read out the responses of both populations in single time bins to perform odor identification, categorization, and generalization. Our results suggest that odor representations in the mushroom body may result from competing optimization constraints to facilitate memorization (sparseness) while enabling identification, classification and generalization.
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