Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?
Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?
复制标题
DOI：
10.1289/ehp12371
复制
发表时间：
2023-08
影响因子：
10.4
通讯作者：
Schneider, Jay S.
中科院分区：
文献类型：
--
作者：
Schneider, Jay S.
儿童铅中毒仍然是美国以及世界其他地方的一个重要公共卫生问题。虽然初级预防是一个主要目标，而且防止儿童中毒至关重要，但探索减少铅对已中毒儿童的神经毒性影响的方法也很重要。铅引起的神经毒性及其相关的不良后果是否被视为“永久性”或“持久性”可能会影响潜在的补救措施被认为是改善儿童铅中毒的结果的方式。本评论的目的是讨论铅对大脑的直接神经毒性效应的持久性和持久性以及这些效应所产生的不良后果。最近的新见解，潜在的缓解铅诱导的神经毒性对大脑和行为的影响被认为是沿着与神经康复的临床信息，建议潜在的策略，改善铅中毒儿童的认知/行为的结果。在铅引起的神经毒性及其后果方面，永久性和持久性之间的区别可能对应对儿童铅暴露问题的公共卫生政策产生广泛影响。永久性一词意味着损害是不可逆转的，几乎没有改善的机会。然而，有证据表明，至少有一些不利的认知/行为后果的铅暴露是持久的，而不是永久的，并可能服从，在适当的情况下，一定程度的缓解。本文作者建议，临床干预性研究应致力于探索最佳的神经康复和富集条件，以刺激可塑性和增强功能，以确定铅诱导脑损伤临床前研究的有希望的结果以及这些影响的缓解可以成功转化为人类的程度。https://doi.org/10.1289/EHP12371
Childhood lead poisoning remains an important public health issue in the United States, as well as elsewhere in the world. Although primary prevention is a major goal and it is critically important to keep children from getting poisoned, it is also important to explore ways to reduce the neurotoxic effects of lead in those children already poisoned. Whether lead-induced neurotoxicity and its related adverse outcomes are viewed as “permanent” or “persistent” may influence the way in which potential remediation efforts are considered for improving outcomes from childhood lead poisoning. The objective of this commentary was to discuss the ideas of permanence and persistence in relation to the direct neurotoxic effects of lead on the brain and the resulting adverse outcomes from these effects. Recent new insights regarding potential mitigation of lead-induced neurotoxic effects on brain and behavior are considered along with clinical information on neurorehabilitation to suggest potential strategies for improving cognitive/behavioral outcomes in lead-poisoned children. The distinction between permanent and persistent in regard to lead-induced neurotoxicity and its resulting outcomes may have broad implications for public health policies in response to the problem of childhood lead exposure. The term permanent implies that the damage is irreversible with little chance of improvement. However, there is evidence that at least some of the adverse cognitive/behavioral outcomes from lead exposure are persistent rather than permanent and potentially amenable, under the appropriate circumstances, to some level of mitigation. This author recommends that clinical, interventional research efforts be devoted to exploring optimal neurorehabilitative and enrichment conditions to stimulate plasticity and enhance functioning to determine the extent to which promising results from preclinical studies of lead-induced brain damage and the mitigation of these effects can be successfully translated to humans. https://doi.org/10.1289/EHP12371
影响因子：
3.4
作者：
Anderson DW;Pothakos K;Schneider JS
通讯作者：
Schneider JS