Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015.

Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008-2015.
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DOI:
10.3201/eid2403.171303
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发表时间:
2018-03
影响因子:
11.8
通讯作者:
Wei S
Wei S
中科院分区:
医学2区
文献类型:
--
作者:
Huang J;Liao Q;Ooi MH;Cowling BJ;Chang Z;Wu P;Liu F;Li Y;Luo L;Yu S;Yu H;Wei S

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接种了肠道病毒 A71 疫苗的儿童仍有感染其他血清型肠道病毒的风险。利用2008-2015年中国国家手足口病(HFMD)监测数据,我们描述了复发性手足口病的流行病学和病毒学特征。共有398,010名手足口病复发患者; 1,767 名患者中有 1,814 例实验室确诊的复发性手足口病:99 例肠道病毒 A71 (EV-A71) 与 EV-A71 重复感染,45 例柯萨奇病毒 A16 (CV-A16) 与 CV-A16 重复感染,364 例其他肠道病毒与其他肠道病毒重复感染,383 例 EV-A71 与 CV-A16 重复感染, CV-A16 与 EV-A71,以及 923 的 EV-A71 或 CV-A16 与其他肠道病毒以及其他肠道病毒与 EV-A71 或 CV-A16。初次发作后 12 个月、24 个月、36 个月、38.8 个月时手足口病复发的概率分别为 1.9%、3.3%、3.9% 和 4.0%。手足口病的严重程度与反复发作或发作之间的时间间隔无关。需要阐明相同肠道病毒血清型手足口病复发的机制,并确认手足口病复发与疾病严重程度无关。
Children who have received the enterovirus A71 vaccine are still at risk for disease with infections of enteroviruses of other serotypes. Using China’s national surveillance data on hand, foot and mouth disease (HFMD) for 2008–2015, we described the epidemiologic and virologic features of recurrent HFMD. A total of 398,010 patients had HFMD recurrence; 1,767 patients had 1,814 cases of recurrent laboratory-confirmed HFMD: 99 reinfections of enterovirus A71 (EV-A71) with EV-A71, 45 of coxsackievirus A16 (CV-A16) with CV-A16, 364 of other enteroviruses with other enteroviruses, 383 of EV-A71 with CV-A16 and CV-A16 with EV-A71, and 923 of EV-A71 or CV-A16 with other enteroviruses and other enteroviruses with EV-A71 or CV-A16. The probability of HFMD recurrence was 1.9% at 12 months, 3.3% at 24 months, 3.9% at 36 months, and 4.0% at 38.8 months after the primary episode. HFMD severity was not associated with recurrent episodes or time interval between episodes. Elucidation of the mechanism underlying HFMD recurrence with the same enterovirus serotype and confirmation that HFMD recurrence is not associated with disease severity is needed.
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