Connected Speech Characteristics of Bengali Speakers With Alzheimer's Disease: Evidence for Language-Specific Diagnostic Markers.
Connected Speech Characteristics of Bengali Speakers With Alzheimer's Disease: Evidence for Language-Specific Diagnostic Markers.
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DOI：
10.3389/fnagi.2021.707628
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发表时间：
2021
影响因子：
4.8
通讯作者：
D Mello TM
中科院分区：
文献类型：
--
作者：
Bose A;Dash NS;Ahmed S;Dutta M;Dutt A;Nandi R;Cheng Y;D Mello TM
背景和目的：关联语音的语音和语言特征为识别、诊断和监测阿尔茨海默病(AD)的进展提供了有价值的工具。我们对AD中连接言语的语言特征的了解主要来自英语使用者；对其他语言使用者(如孟加拉语)的语言缺陷模式知之甚少。孟加拉语是印度-雅利安语系中一种高度变化的支持Drop的语言。它是世界上第七种最常用的语言，但到目前为止，还没有研究调查患有AD的孟加拉语者的语言障碍情况。这项研究的目的是描述关联言语产生的特征，并确定患有AD的孟加拉语者受到影响的语言特征。方法：参与者是来自印度加尔各答大都市的6名说孟加拉语的AD患者和8名匹配的对照组。故事样本是用孟加拉语用《青蛙故事》获得的。使用定量产出分析和正确信息单元分析对样本进行分析，以量化言语产出的六个不同方面：语速、结构和句法措施、词汇措施、形态和屈折措施、语义措施以及自发性和流利性中断的措施。结果和结论：与现有的英语使用者的文献一致，孟加拉AD参与者表现出语速减慢，句子形式和结构简单，语义内容减少。关键的是，在孟加拉特定的语言特征领域出现了与说英语的文学作品的不同，例如孟加拉语的支持下降的性质及其名词性和动词系统的屈折属性。孟加拉AD参与者产生的代词较少，这与英语AD参与者过度使用代词形成了直接对比。在产生名词性和动词性变化方面没有明显的困难。然而，名词屈折变化的类型差异是明显的；这些变化的特点是AD使用者使用更简单的屈折变化特征。这项研究是第一次表征孟加拉AD参与者的连接言语产生，是朝着AD语言特异性临床标记物发展的重要一步。它还提供了一个跨语言比较的框架，用于跨结构不同和未被充分开发的语言进行比较。
Background and aim: Speech and language characteristics of connected speech provide a valuable tool for identifying, diagnosing and monitoring progression in Alzheimer's Disease (AD). Our knowledge of linguistic features of connected speech in AD is primarily derived from English speakers; very little is known regarding patterns of linguistic deficits in speakers of other languages, such as Bengali. Bengali is a highly inflected pro-drop language from the Indo-Aryan language family. It is the seventh most spoken language in the world, yet to date, no studies have investigated the profile of linguistic impairments in Bengali speakers with AD. The aim of this study was to characterize connected speech production and identify the linguistic features affected in Bengali speakers with AD. Methods: Participants were six Bengali speaking AD patients and eight matched controls from the urban metropolis, Kolkata, India. Narrative samples were elicited in Bengali using the Frog Story. Samples were analyzed using the Quantitative Production Analysis and the Correct Information Unit analyses to quantify six different aspects of speech production: speech rate, structural and syntactic measures, lexical measures, morphological and inflectional measures, semantic measures and measure of spontaneity and fluency disruptions. Results and conclusions: In line with the extant literature from English speakers, the Bengali AD participants demonstrated decreased speech rate, simplicity of sentence forms and structures, and reduced semantic content. Critically, differences with English speakers' literature emerged in the domains of Bengali specific linguistic features, such as the pro-drop nature of Bengali and its inflectional properties of nominal and verbal systems. Bengali AD participants produced fewer pronouns, which is in direct contrast with the overuse of pronouns by English AD participants. No obvious difficulty in producing nominal and verbal inflections was evident. However, differences in the type of noun inflections were evident; these were characterized by simpler inflectional features used by AD speakers. This study represents the first of its kind to characterize connected speech production in Bengali AD participants and is a significant step forward toward the development of language-specific clinical markers in AD. It also provides a framework for cross-linguistic comparisons across structurally distinct and under-explored languages.
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DOI：
10.1093/brain/awt269
发表时间：
2013-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Ahmed S;Haigh AM;de Jager CA;Garrard P
通讯作者：
Garrard P
影响因子：
2.6
作者：
Crawford, JR;Garthwaite, PH
通讯作者：
Garthwaite, PH
影响因子：
1.8
作者：
Auclair-Ouellet, Noemie;Pythoud, Pauline;Fossard, Marion
通讯作者：
Fossard, Marion
影响因子：
3.6
作者：
Carlomagno, S;Santoro, A;Marini, A
通讯作者：
Marini, A
影响因子：
3.4
作者：
Crawford, John R.;Garthwaite, Paul H.;Porter, Sara
通讯作者：
Porter, Sara