Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents.
Natural Alkaloids and Heterocycles as G-Quadruplex Ligands and Potential Anticancer Agents.
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天然生物碱和杂环化合物作为 G-四联体配体和潜在的抗癌剂
DOI：
10.3390/molecules23020493
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发表时间：
2018-02-23
期刊：
影响因子：
--
通讯作者：
Chen SB
中科院分区：
文献类型：
--
作者：
Che T;Wang YQ;Huang ZL;Tan JH;Huang ZS;Chen SB
G-四链体是在富含鸟嘌呤的序列中形成的四链核酸二级结构。G-四链体广泛分布于人类基因组和转录组的功能区域，如人类端粒、癌基因启动子区、复制起始位点和非翻译区。发现许多G-四链体形成序列与癌症相关，因此，这些非规范核酸结构被认为是具有新作用机制的癌症治疗剂的有吸引力的分子靶标。本文综述了本实验室近年来在以G-四链体为靶点的天然生物碱及其衍生物的研究进展。
G-quadruplexes are four-stranded nucleic acid secondary structures that are formed in guanine-rich sequences. G-quadruplexes are widely distributed in functional regions of the human genome and transcriptome, such as human telomeres, oncogene promoter regions, replication initiation sites, and untranslated regions. Many G-quadruplex-forming sequences are found to be associated with cancer, and thus, these non-canonical nucleic acid structures are considered to be attractive molecular targets for cancer therapeutics with novel mechanisms of action. In this mini review, we summarize recent advances made by our lab in the study of G-quadruplex-targeted natural alkaloids and their derivatives toward the development of potential anticancer agents.
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