“So is science …” 1 : No evidence for neocytolysis on descending the mountains (Response to Rice and Gunga)
“So is science …” 1 : No evidence for neocytolysis on descending the mountains (Response to Rice and Gunga)
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â科学也是如此 â 1：没有证据表明下山时会发生新细胞溶解（对 Rice 和 Gunga 的回应）
DOI：
10.1111/apha.13709
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发表时间：
2021
影响因子：
6.3
通讯作者：
H. Mairbäurl
中科院分区：
文献类型：
--
作者：
Recktenwald;L. Kaestner;A. Y. Bogdanova;G. Minetti;M. Klein;H. Mairbäurl
“科学也是如此”，赖斯和冈加1指出，科学是对结果的解释，很容易用不同的假设来解释实验观察。测量的支持参数越多，假设就越有可能反映实际机制。赖斯和贡加1评论了Klein等人(不是Mairbäurl等人！)2的一项研究，该研究旨在提供更严格的证据和机制，导致从瑞士Jungfraujoch研究站3450米的19天停留后总Hb质量下降，以测试和加强新细胞溶解的假说，即当EPO水平下降时，年轻红细胞部分的选择性破坏。这一假说最早是由Alfrey等人(3，4)提出的，其基础是宇航员从太空任务返回后，标记有51Cr的红细胞的存活曲线向上偏转。结论是，51Cr标记红细胞比例的相对增加，在当时代表了相当衰老的红细胞数量，这必须是选择性地去除标记51Cr后产生的红细胞，即细胞(新生细胞)的“年轻”部分。3、4另一种假说，由于血液中促红细胞生成素水平下降导致红细胞生成率下降而导致缺乏年轻红细胞，这一假说已经被搁置一边，因为它被认为是“无休止的缓慢”1，而破坏将提供一种快速变化的手段。令我们非常惊讶的是，我们的结果表明，在从高海拔下降后促红细胞生成素下降之前产生的年轻红细胞并没有被破坏，但在循环血液中可以很好地检测到。然而，非常年轻的网织红细胞的一部分丢失了。因此，我们得出的结论是，从高海拔降落后，总血红蛋白质量迅速下降不能用新细胞溶解(即溶解、破坏)来解释，而可以用红细胞生成率降低来解释。2我们的假设似乎是合理的，因为
“So is science” commented Rice and Gunga1 pointing to the fact that science is the interpretation of results, where it is easily possible to explain an experimental observation with different hypotheses. The more supporting parameters are measured, the more likely a hypothesis reflects the actual mechanism. Rice and Gunga1 commented on a study by Klein et al (not Mairbäurl et al!) 2 set out to provide more stringent evidence and mechanisms causing the decrease in total Hb mass after descent from a 19-day stay at 3450 m at the Jungfraujoch Research Station in Switzerland to test and strengthen the hypothesis of neocytolysis, that is, the selective destruction of the fraction of young erythrocytes, when EPO levels drop. This hypothesis, first proposed by Alfrey et al, 3, 4 was based on an upward deflection of survival curves of 51Cr-labelled erythrocytes after astronauts returned from space missions. It was concluded that this relative increase in the proportion of 51Cr-labelled erythrocytes, which at that time point represented a rather senescent erythrocyte population, had to be caused by selective removal of those erythrocytes produced after the labelling with 51Cr, that is, the" younger" fraction of cells (neocytes). 3, 4 The alternate hypothesis, lack of young erythrocytes due to a decreased rate of erythropoiesis subsequent to a decrease in blood EPO levels, had been put aside because it was thought to be" interminably slow," 1 whereas destruction would provide a means for rapid change.To our big surprise, our results indicated that the young erythrocytes produced prior to the decrease in EPO after descent from high altitude had not been destroyed but were well detectable in circulating blood. However, the fraction of the very young reticulocytes was missing. We concluded therefore that the quite rapid decrease in total haemoglobin mass upon descent from high altitude cannot be explained by neocytolysis (ie, lysis, destruction), but might as well be explained by decreasing the erythropoietic rate. 2 Our assumption appeared justified because a decrease in the
影响因子：
6.3
作者：
L. Rice;H. Gunga
通讯作者：
H. Gunga
影响因子：
6.3
作者：
Klein, Marie;Kaestner, Lars;Mairbaeurl, Heimo
通讯作者：
Mairbaeurl, Heimo
影响因子：
1.6
作者：
HUFF, RL;LAWRENCE, JH;HENNESSY, TG
通讯作者：
HENNESSY, TG