Autophagy in peritoneal fibrosis.
Autophagy in peritoneal fibrosis.
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DOI：
10.3389/fphys.2023.1187207
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发表时间：
2023
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
腹膜透析(PD)是被广泛接受的终末期肾病(ESRD)患者的肾脏替代疗法。长期腹膜透析患者腹膜的形态和功能发生改变。腹膜纤维化是一种常见的腹膜透析相关并发症，最终导致腹膜损伤和腹膜超滤衰竭。自噬是一种“自噬”的细胞过程，其中受损的细胞器、蛋白质聚集体和致病微生物被降解，以维持细胞内环境的动态平衡和细胞的生存。越来越多的证据表明，自噬参与了各种器官的纤维化进程，包括肾纤维化和肝纤维化。包括高糖腹膜透析液(HGPDS)在内的多种危险因素刺激了人腹膜间皮细胞(HPMC)自噬的激活，自噬参与了腹膜间皮细胞(HPMC)的PF进展。然而，自噬在PF进展中的潜在作用和机制仍不清楚。在这篇综述中，我们讨论了自噬在PF中的关键作用和可能的机制，以期为未来PF的治疗策略及其局限性提供新的视角。
Peritoneal dialysis (PD) is a widely accepted renal replacement therapy for patients with end-stage renal disease (ESRD). Morphological and functional changes occur in the peritoneal membranes (PMs) of patients undergoing long-term PD. Peritoneal fibrosis (PF) is a common PD-related complication that ultimately leads to PM injury and peritoneal ultrafiltration failure. Autophagy is a cellular process of “self-eating” wherein damaged organelles, protein aggregates, and pathogenic microbes are degraded to maintain intracellular environment homeostasis and cell survival. Growing evidence shows that autophagy is involved in fibrosis progression, including renal fibrosis and hepatic fibrosis, in various organs. Multiple risk factors, including high-glucose peritoneal dialysis solution (HGPDS), stimulate the activation of autophagy, which participates in PF progression, in human peritoneal mesothelial cells (HPMCs). Nevertheless, the underlying roles and mechanisms of autophagy in PF progression remain unclear. In this review, we discuss the key roles and potential mechanisms of autophagy in PF to offer novel perspectives on future therapy strategies for PF and their limitations.
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