Regular Aerobic Voluntary Exercise Increased Oxytocin in Female Mice: The Cause of Decreased Anxiety and Increased Empathy-Like Behaviors
Regular Aerobic Voluntary Exercise Increased Oxytocin in Female Mice: The Cause of Decreased Anxiety and Increased Empathy-Like Behaviors
复制标题
定期有氧自愿运动会增加雌性小鼠的催产素：焦虑减少和类同理心行为增加的原因
作者：
Oğuz Yüksel;M. Ates;S. Kizildag;Z. Yüce;B. Koc;Sevim Kandis;Güven Güvendi;Aslı Karakiliç;H. Gümüş;N. Uysal
背景：众所周知，有规律的身体活动可以减少焦虑。低焦虑水平会影响情绪、情感和同理心。催产素是一种强大的荷尔蒙，它调节着社会互动、性生殖、母婴联结、乳汁分泌、同理心和焦虑。移情是生活共同体中的一种重要行为，对于运动员在体育比赛和日常生活中也很重要，因为运动员也是人们的榜样。目的：探讨自愿性体力活动对催产素、焦虑和共情水平的影响以及它们之间的关系。研究设计：动物实验。方法：将雄性和雌性小鼠置于转轮笼中进行为期6周的运动。分别采用助人行为测验、高架十字迷宫测验和旷场测验评价其同情和焦虑水平。然后测量大脑和血液中的催产素水平。结果如下：运动组的两种性别的同理心行为都得到了改善（运动组的两种性别的开门时间都减少了，p =0.0001）。作为对运动的反应，雌性小鼠的大脑和血清催产素水平均增加（均为p=0.0001）;然而，在雄性小鼠中，催产素水平仅在大脑中增加（p<0.05）。所有运动组的焦虑水平均降低（在旷场测试的中间区域花费的时间增加，两种性别，p=0.002;在高架十字迷宫测试的开放臂花费的时间增加，女性p=0.004，男性p=0.0001）。女性血清催产素水平与帮助行为设备开门时间呈强负相关，女性脑催产素水平与帮助行为设备开门时间呈中度负相关。然而，男性的大脑和血清催产素水平与共情行为之间没有相关性。但是，在两种性别中，低焦虑指标与大脑和血清催产素水平之间都存在非常强的正相关性。结论：自愿的身体活动可以减少小鼠的焦虑并增加同理心行为;这与雌性小鼠催产素水平的增加有关，但与雄性小鼠无关。运动对男性焦虑和共情脑通路影响的机制有待进一步研究。
Background: It is known that regular physical activity reduces anxiety. Low anxiety levels affect mood, emotions, and empathy. Oxytocin is a powerful hormone that regulates social interaction, sexual reproduction, maternal–infant bonding, milk release, empathy, and anxiety. Empathy is an important behavior in the living community; and also important for sportsmen during sportive competition and daily living life, because sportsmen are also role model of people. Aims: To investigate the effects of voluntary physical activity on oxytocin, anxiety, and empathy levels as well as the relationship between them. Study Design: Animal experiment. Methods: Male and female mice were made to exercise in running wheel cages for 6 weeks. Their empathy and anxiety levels were evaluated by using Helping Behavior test and elevated plus maze and open field test, respectively. And then the brain and blood oxytocin levels were measured. Results: Empathy-like behavior was improved in both genders of the exercise groups (door-opening time decreased in both genders of exercise groups, p for both=0.0001). As a response to exercise, both the brain and serum oxytocin levels increased in female mice (both of p=0.0001); however, in males, oxytocin levels increased in only the brain (p<0.05). Anxiety levels decreased in all the exercise groups (increased time spent in the middle area of open field test, both genders, p=0.002; increased time spent in the open arms of elevated plus maze test, females p=0.004, males p=0.0001). There was a strong negative correlation between serum oxytocin levels and door opening time of helping behavior equipment, and moderate negative correlation was found between the brain oxytocin levels and door-opening time of helping behavior equipment in females. However, there was no correlation between both the brain and serum oxytocin levels and empathy behavior in males. But there were very strong positive correlations between low anxiety indicators and both the brain and serum oxytocin levels in both the genders. Conclusion: Voluntary physical activity decreases anxiety and increases empathy-like behavior in mice; which is associated with increased oxytocin levels in female mice but not in male mice. Further research is required to investigate the mechanisms of exercise effect on anxiety and empathic brain pathways in males.
DOI：
10.1152/ajpregu.2000.278.6.r1474
发表时间：
2000-06-01
影响因子：
2.8
作者：
Braga, DC;Mori, E;Michelini, LC
通讯作者：
Michelini, LC
影响因子：
5.8
作者：
Hew-Butler, Tamara;Noakes, Timothy D.;Verbalis, Joseph G.
通讯作者：
Verbalis, Joseph G.