Temporal lobe epilepsy and surgery selectively alter the dorsal, not the ventral, default-mode network.
Temporal lobe epilepsy and surgery selectively alter the dorsal, not the ventral, default-mode network.
复制标题
DOI：
10.3389/fneur.2014.00023
复制
发表时间：
2014
影响因子：
3.4
通讯作者：
Tracy JI
中科院分区：
文献类型：
--
作者：
Doucet GE;Skidmore C;Evans J;Sharan A;Sperling MR;Pustina D;Tracy JI
默认模式网络（DMN）是一种主要的静态网络。它可以分为两个不同的网络：一个是由背侧和前部区域组成[称为背侧DMN（dDMN）]，而另一个涉及更后部的区域[称为腹侧DMN（vDMN）]。到目前为止，还没有研究调查颞叶癫痫（TLE）对这些网络的潜在明显影响。在此背景下，我们探讨了TLE和前颞叶切除术（ATL）对dDMN和vDMN的影响。我们利用两个静息状态fMRI会议从左，右TLE患者（术前/术后）和正常对照组（会议1/2）。使用独立成分分析，我们确定了这两个网络。然后，我们评估了各组之间以及整个扫描会话中每个网络的空间范围差异。结果显示，术前，dDMN在三组之间显示出比vDMN更大的差异，并且更特别地在右和左TLE之间比在TLE患者和对照组之间更大。在术后变化方面，在两个TLE组中，dDMN也表现出比vDMN更大的变化。对于vDMN，唯一的变化涉及每个ATL组的切除颞叶。对于dDMN，左ATL组在发作期颞叶外的几个区域显示术后增加。相比之下，右ATL组的额叶皮层显示出大幅减少。结果突出表明，两个DMN不受TLE和ATL的影响，在一个等效的方式。重要的是，dDMN受影响更大，右ATL比左ATL具有更有害的影响。我们是第一个强调dDMN比vDMN更强烈地承受TLE的负面影响，这表明病理学方面和DM子网络活动之间存在相互作用。我们的研究结果有影响，了解TLE和随后的ATL的不同DMN实现的功能的影响。
The default-mode network (DMN) is a major resting-state network. It can be divided in two distinct networks: one is composed of dorsal and anterior regions [referred to as the dorsal DMN (dDMN)], while the other involves the more posterior regions [referred to as the ventral DMN (vDMN)]. To date, no studies have investigated the potentially distinct impact of temporal lobe epilepsy (TLE) on these networks. In this context, we explored the effect of TLE and anterior temporal lobectomy (ATL) on the dDMN and vDMN. We utilized two resting-state fMRI sessions from left, right TLE patients (pre-/post-surgery) and normal controls (sessions 1/2). Using independent component analysis, we identified the two networks. We then evaluated for differences in spatial extent for each network between the groups, and across the scanning sessions. The results revealed that, pre-surgery, the dDMN showed larger differences between the three groups than the vDMN, and more particularly between right and left TLE than between the TLE patients and controls. In terms of change post-surgery, in both TLE groups, the dDMN also demonstrated larger changes than the vDMN. For the vDMN, the only changes involved the resected temporal lobe for each ATL group. For the dDMN, the left ATL group showed post-surgical increases in several regions outside the ictal temporal lobe. In contrast, the right ATL group displayed a large reduction in the frontal cortex. The results highlight that the two DMNs are not impacted by TLE and ATL in an equivalent fashion. Importantly, the dDMN was the more affected, with right ATL having a more deleterious effects than left ATL. We are the first to highlight that the dDMN more strongly bears the negative impact of TLE than the vDMN, suggesting there is an interaction between the side of pathology and DM sub-network activity. Our findings have implications for understanding the impact TLE and subsequent ATL on the functions implemented by the distinct DMNs.
登录
查看更多内容
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
4.8
作者：
Doucet, Gaelle;Osipowicz, Karol;Sharan, Ashwini;Sperling, Michael R.;Tracy, Joseph I.
通讯作者：
Tracy, Joseph I.
影响因子：
3.7
作者：
Shirer, W. R.;Ryali, S.;Greicius, M. D.
通讯作者：
Greicius, M. D.
影响因子：
11.2
作者：
Helmstaedter, C;Kurthen, M;Elger, CE
通讯作者：
Elger, CE
影响因子：
5.6
作者：
McCormick, Cornelia;Quraan, Maher;McAndrews, Mary Pat
通讯作者：
McAndrews, Mary Pat