Extratemporal functional connectivity impairments at rest are related to memory performance in mesial temporal epilepsy.
Extratemporal functional connectivity impairments at rest are related to memory performance in mesial temporal epilepsy.
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DOI：
10.1002/hbm.22059
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发表时间：
2013-09
影响因子：
4.8
通讯作者：
Tracy, Joseph I.
中科院分区：
文献类型：
--
作者：
Doucet, Gaelle;Osipowicz, Karol;Sharan, Ashwini;Sperling, Michael R.;Tracy, Joseph I.
内侧颞叶癫痫（MTLE）是局灶性癫痫最常见的形式。在休息时，有证据表明，MTLE的大脑异常不仅限于致痫区域，而是扩展到整个大脑。MTLE患者患有情景记忆缺陷也是公认的。因此，我们研究了功能性连接之间的关系，看到在休息和情节记忆障碍的MTLE功能磁共振成像。我们专注于休息状态BOLD活动和评估是否功能连接（FC）的差异出现从MTL种子在左，右MTLE组，与健康对照组相比。结果显示，两组患者的FC均显着降低，局限于角回、丘脑、后扣带回和内侧额叶皮质。我们发现，左侧非病理性MTL和内侧额叶皮质之间的FC与右侧MTLE患者的非语言记忆测试的延迟回忆分数呈正相关，这表明潜在的适应性变化，以保持这种记忆功能。与此相反，我们观察到的文字记忆测试和FC之间的左侧病理MTL和后扣带在左侧MTLE患者，提示潜在的功能性适应不良的病理半球的变化。总的来说，本研究提供了一些迹象表明，左MTLE可能比右MTLE患者更损害正常的功能连接。我们的数据还表明，模式的额外的时间FC可能会有所不同的功能的情节记忆材料和每个半球的认知重组的能力。
Mesial temporal lobe epilepsy (MTLE) is the most frequent form of focal epilepsy. At rest, there is evidence that brain abnormalities in MTLE are not limited to the epileptogenic region, but extend throughout the whole brain. It is also well established that MTLE patients suffer from episodic memory deficits. Thus, we investigated the relation between the functional connectivity seen at rest in fMRI and episodic memory impairments in MTLE. We focused on resting state BOLD activity and evaluated whether functional connectivity (FC) differences emerge from MTL seeds in left and right MTLE groups, compared with healthy controls. Results revealed significant FC reductions in both patient groups, localized in angular gyri, thalami, posterior cingulum and medial frontal cortex. We found that the FC between the left non-pathologic MTL and the medial frontal cortex was positively correlated with the delayed recall score of a non-verbal memory test in right MTLE patients, suggesting potential adaptive changes to preserve this memory function. In contrast, we observed a negative correlation between a verbal memory test and the FC between the left pathologic MTL and posterior cingulum in left MTLE patients, suggesting potential functional maladaptative changes in the pathologic hemisphere. Overall, the present study provides some indication that left MTLE may be more impairing than right MTLE patients to normative functional connectivity. Our data also indicates that the pattern of extra-temporal FC may vary as a function of episodic memory material and each hemisphere’s capacity for cognitive reorganization.
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影响因子：
5.6
作者：
Bonilha L;Edwards JC;Kinsman SL;Morgan PS;Fridriksson J;Rorden C;Rumboldt Z;Roberts DR;Eckert MA;Halford JJ
通讯作者：
Halford JJ
影响因子：
--
作者：
MILLER, LA;MUNOZ, DG;FINMORE, M
通讯作者：
FINMORE, M
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
4.8
作者：
Alessio, Andrea;Pereira, Fabricio R. S.;Cendes, Fernando
通讯作者：
Cendes, Fernando
影响因子：
2.6
作者：
Alessio, A;Damasceno, BP;Cendes, F
通讯作者：
Cendes, F