A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration.

A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration.
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DOI:
10.1016/j.devcel.2018.06.018
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发表时间:
2018-07-16
期刊:
影响因子:
11.8
通讯作者:
Rando TA
Rando TA
中科院分区:
生物学1区
文献类型:
--
作者:
Wosczyna MN;Rando TA

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由于组织特异性肌肉干细胞(MUSCs)的活性,骨骼肌具有非凡的再生能力。因此,这些细胞在研究骨骼肌再生的细胞过程中受到了最多的关注。然而,重建这一组织的有效能力还取决于局部环境中的额外细胞,因为扰乱它们的正常贡献往往会导致再生不完全。在这里,我们回顾了这些有助于再生过程的额外细胞。了解这些细胞群体之间的复杂相互作用有可能导致有助于促进正常骨骼肌再生的治疗方法,在这一过程是次优的条件下。
Skeletal muscle has an extraordinary regenerative capacity due to the activity of tissue-specific muscle stem cells (MuSCs). Consequently, these cells have received the most attention in studies investigating the cellular processes of skeletal muscle regeneration. However, efficient capacity to rebuild this tissue also depends on additional cells in the local milieu, as disrupting their normal contributions often leads to incomplete regeneration. Here, we review these additional cells that contribute to the regenerative process. Understanding the complex interactions between and among these cell populations has the potential to lead to therapies that will help promote normal skeletal muscle regeneration under conditions where this process is suboptimal.
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