S100A10 and its binding partners in depression and antidepressant actions.
S100A10 and its binding partners in depression and antidepressant actions.
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DOI：
10.3389/fnmol.2022.953066
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发表时间：
2022
影响因子：
4.8
通讯作者：
Kim, Yong
中科院分区：
文献类型：
--
作者：
Chen, Michelle X.;Oh, Yong-Seok;Kim, Yong
S100 A10（p11）是抑郁症和抗抑郁作用的神经生物学中的新兴参与者。p11最初被认为是5-羟色胺受体（5-HTR）运输和多巴胺能传递的调节剂，尽管新发现的p11结合伴侣和这些蛋白的神经生物学研究揭示了p11在多巴胺能传递、钙信号传导和与染色质重塑、组蛋白修饰和基因转录相关的核事件调节中的多功能作用。这篇评论文章重点关注p11在大脑中的直接结合伙伴，包括5-HTR、mGluR 5、膜联蛋白A2、Ahnak、Smarca 3和Supt 6 h，以及它们在神经元功能中的作用，特别是在抑郁样行为的背景下以及小鼠抗抑郁药物治疗的行为影响。此外，我们还讨论了最近发现的p11通路在多种类型的神经元和非神经元细胞的神经生物学见解，并为未来的研究提出了主要的剩余问题。
S100A10 (p11) is an emerging player in the neurobiology of depression and antidepressant actions. p11 was initially thought to be a modulator of serotonin receptor (5-HTR) trafficking and serotonergic transmission, though newly identified binding partners of p11 and neurobiological studies of these proteins have shed light on multifunctional roles for p11 in the regulation of glutamatergic transmission, calcium signaling and nuclear events related to chromatin remodeling, histone modification, and gene transcription. This review article focuses on direct binding partners of p11 in the brain including 5-HTRs, mGluR5, annexin A2, Ahnak, Smarca3, and Supt6h, as well as their roles in neuronal function, particularly in the context of depressive-like behavior as well as behavioral effects of antidepressant drug treatments in mice. In addition, we discuss neurobiological insights from recently uncovered p11 pathways in multiple types of neurons and non-neuronal cells and cast major remaining questions for future studies.
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影响因子：
10.6
作者：
Arango-Lievano, Margarita;Schwarz, Justin T.;Vernov, Mary;Wilkinson, Matthew B.;Bradbury, Kathryn;Feliz, Akira;Marongiu, Roberta;Gelfand, Yaroslav;Warner-Schmidt, Jennifer;Nestler, Eric J.;Greengard, Paul;Russo, Scott J.;Kaplitt, Michael G.
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Kaplitt, Michael G.
影响因子：
4.8
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Bhatti, Dionnet L.;Medrihan, Lucian;Chen, Michelle X.;Jin, Junghee;McCabe, Kathryn A.;Wang, Wei;Azevedo, Estefania P.;Ledo, Jose H.;Kim, Yong
通讯作者：
Kim, Yong
影响因子：
4.8
作者：
Ding, H;Benotmane, AM;Belayew, A
通讯作者：
Belayew, A
影响因子：
17.1
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Alexander B;Warner-Schmidt J;Eriksson T;Tamminga C;Arango-Lievano M;Ghose S;Vernov M;Stavarache M;Musatov S;Flajolet M;Svenningsson P;Greengard P;Kaplitt MG
通讯作者：
Kaplitt MG
影响因子：
6.7
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Bhat, Shambhu;Dao, David T.;Terrillion, Chantelle E.;Arad, Michal;Smith, Robert J.;Soldatov, Nikolai M.;Gould, Todd D.
通讯作者：
Gould, Todd D.