No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.
No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.
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中国核心家族中卷曲相关蛋白基因的多态性与峰值骨密度没有关联。
DOI：
10.1186/1471-2350-11-1
复制
发表时间：
2010-01-01
影响因子：
--
通讯作者：
Yu JB
中科院分区：
文献类型：
--
作者：
Gao G;Zhang ZL;He JW;Zhang H;Yue H;Hu WW;Gu JM;Fu WZ;Hu YQ;Li M;Liu YJ;Yu JB
Wnt/β-catenin信号通路在骨骼发育中起着重要作用。卷曲相关蛋白（FRZB）是这一通路的拮抗剂，其多态性可引起骨密度（BMD）的变化。在这项研究中，我们分析了FRZB基因型和峰值骨密度变化的两个相对较大的样本的中国女性后代和男性后代的核心家庭的脊柱和髋部之间的关联。我们招募了来自401个女性后代核心家庭的1，260名受试者和来自427个男性后代核心家庭的1，296名受试者，并对跨越整个FRZB基因的4个标签单核苷酸多态性（tagSNPs）（rs6433993，rs409238，rs288324和rs4666865）进行了基因分型。本研究未选择与髋关节骨关节炎相关的SNP rs288326和rs7775，因为它们在中国人群中的次要等位基因频率（MAF）较低。采用定量传递不平衡检验（QTDT）分析每个SNP和单倍型与女性和男性后代核心家庭峰值BMD的关联。在女性后代核心家庭中，我们没有发现任何证据表明单一SNP或单倍型与脊柱或髋关节的峰值BMD之间存在关联。在男性后代的核心家庭，没有观察到任何单核苷酸多态性或单倍型的家庭内的关联，虽然一个显着的总关联之间发现rs4666865和脊柱骨密度（P = 0.0299）。我们的研究结果表明，FRZB的自然变异不是中国女性或男性峰值BMD变异的主要贡献者。由于FRZB基因型可能存在种族差异，需要在不同人群中进行其他研究来证实这一结果。
The Wnt/beta-catenin signaling pathway plays an important role in skeletal development. Polymorphisms of frizzled-related protein (FRZB), an antagonist of this pathway, may generate variations in bone mineral density (BMD). In this study, we analyzed the association between FRZB genotypes and peak BMD variation in the spines and hips of two relatively large samples of Chinese female-offspring and male-offspring nuclear families. We recruited 1,260 subjects from 401 female-offspring nuclear families and 1,296 subjects from 427 male-offspring nuclear families and genotyped four tagging single nucleotide polymorphisms (tagSNPs) (rs6433993, rs409238, rs288324, and rs4666865) spanning the entire FRZB gene. The SNPs rs288326 and rs7775, which are associated with hip osteoarthritis, were not selected in this study because of their low minor allele frequencies (MAFs) in Chinese people. The quantitative transmission disequilibrium test (QTDT) was used to analyze the association between each SNP and haplotype with peak BMD in female- and male-offspring nuclear families. In the female-offspring nuclear families, we found no evidence of an association between either single SNPs or haplotypes and peak BMD in the spine or hip. In the male-offspring nuclear families, no within-family association was observed for either SNPs or haplotypes, although a significant total association was found between rs4666865 and spine BMD (P = 0.0299). Our results suggest that natural variation in FRZB is not a major contributor to the observed variability in peak BMD in either Chinese females or males. Because ethnic differences in the FRZB genotypes may exist, other studies in different population are required to confirm such results.
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DOI：
10.1016/s0006-291x(02)00824-0
发表时间：
2002-08-09
影响因子：
3.1
作者：
Kim, SJ;Im, DS;Chun, JS
通讯作者：
Chun, JS
影响因子：
64.5
作者：
Gong, YQ;Slee, RB;Warman, ML
通讯作者：
Warman, ML
没有证据表明人类 Alpha2-HS 糖蛋白基因与中国核心家族骨矿物质密度变异之间存在联系和/或关联
影响因子：
4.2
作者：
Liu, XH;Liu, YJ;Deng, HW
通讯作者：
Deng, HW
影响因子：
6.2
作者：
McGuigan, FEA;Murray, L;Ralston, SH
通讯作者：
Ralston, SH
影响因子：
--
作者：
Bodine, PVN;Zhao, WG;Komm, BS
通讯作者：
Komm, BS