T-lymphocyte subpopulation abnormalities in apparently healthy patients with hemophilia.
T-lymphocyte subpopulation abnormalities in apparently healthy patients with hemophilia.
复制标题
表面健康的血友病患者 T 淋巴细胞亚群异常。
DOI：
--
复制
发表时间：
1983
影响因子：
39.2
通讯作者：
G. Hunninghake
中科院分区：
文献类型：
--
作者：
J. Goldsmith;P. Moseley;M. Monick;M. Brady;G. Hunninghake
在12个明显健康的异性恋成人血友病患者的T淋巴细胞群进行了检查，以确定这些患者是否有异常的淋巴细胞亚群类似的同性恋男子，海地难民，和麻醉品成瘾者。12例患者中有9例的辅助细胞与抑制细胞比率显著降低（[0.86 +/- 0.14]：1）。这些异常与先前描述的两名血友病重症患者卡氏肺孢子虫肺炎和同性恋男性的异常相似。辅助性T细胞与抑制性T细胞比例的异常可能与血友病患者持续暴露于商业凝血因子浓缩物有关。然而，这些具有异常T淋巴细胞亚群的患者保持健康。目前，没有足够的证据支持血友病患者的治疗实践的改变。
T-lymphocyte populations in 12 apparently healthy heterosexual adult patients with hemophilia have been examined to ascertain if these patients have abnormalities in their lymphocyte subpopulations similar to those in homosexual men, Haitian refugees, and narcotic addicts. A striking reduction in the helper to suppressor cell ratio ([0.86 +/- 0.14]:1) was found in 9 of the 12 patients. These abnormalities were similar to those previously described in two patients with hemophilia critically ill with Pneumocystis carinii pneumonia, and in homosexual men. The abnormality in the ratio of helper to suppressor T cells may be related to the continual exposure of patients with hemophilia to commercial clotting factor concentrates. However, these patients with abnormal T-lymphocyte subpopulations remain healthy. At present there is insufficient evidence to advocate a change in therapeutic practices in patients with hemophilia.
影响因子：
39.2
作者：
MORRIS, L;DISTENFELD, A;KARPATKIN, S
通讯作者：
KARPATKIN, S