A Meta-Prediction of Methylenetetrahydrofolate-Reductase Polymorphisms and Air Pollution Increased the Risk of Ischemic Heart Diseases Worldwide.
A Meta-Prediction of Methylenetetrahydrofolate-Reductase Polymorphisms and Air Pollution Increased the Risk of Ischemic Heart Diseases Worldwide.
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甲基环酸还酸还原酶多态性和空气污染的元预测增加了全球缺血性心脏病的风险。
DOI：
10.3390/ijerph15071453
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发表时间：
2018-07-10
影响因子：
--
通讯作者：
Shiao SPK
中科院分区：
文献类型：
--
作者：
Chen ZF;Young L;Yu CH;Shiao SPK
缺血性心脏病（IHD）是世界范围内的主要死亡原因之一。亚甲基四氢叶酸还原酶（MTHFR）多态性与IHD风险相关，但研究结果存在异质性。本荟萃分析的目的是通过整合基于机器学习的分析来提供最新的评估，以检查MTHFR多态性与各种亚型IHD风险之间相关性的潜在异质性来源，以及空气污染对MTHFR多态性和IHD风险的可能影响。对各种数据库进行了全面检索，以找到123项关于MTHFR C677 T的研究（29，697例病例和31，028例对照）和18项关于MTHFR A1298 C的研究（7158例病例和5482例对照）。总体而言，MTHFR 677多态性是IHD的风险（TT：风险比（RR）= 1.23，p < 0.0001; CT：RR = 1.04，p = 0.0028，TT + CT：RR = 1.09，p < 0.0001）。相比之下，MTHFR 677 CC野生型对于总体群体具有针对IHD的保护性（RR = 0.91，p < 0.00001）。MTHFR C677 T多态性（RR >2）导致IHD风险升高的三个国家包括印度、土耳其和突尼斯。Meta预测分析显示，在病例组和对照组中，空气污染增加与MTHFR 677 TT和CT多态性增加相关（p < 0.05），空气污染增加导致IHD风险增加的趋势。这些结果将潜在的炎症途径与空气污染和叶酸途径与MTHFR多态性联系起来。未来的干预研究可以设计来减轻MTHFR酶缺陷导致的基因多态性，以防止IHD的高危人群。
Ischemic heart disease (IHD) is among the leading causes of death worldwide. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been associated with IHD risk, but the findings presented with heterogeneity. The purpose of the present meta-analysis was to provide an updated evaluation by integrating machine-learning based analytics to examine the potential source of heterogeneity on the associations between MTHFR polymorphisms and the risk of various subtypes of IHD, as well as the possible impact of air pollution on MTHFR polymorphisms and IHD risks. A comprehensive search of various databases was conducted to locate 123 studies (29,697 cases and 31,028 controls) for MTHFR C677T, and 18 studies (7158 cases and 5482 controls) for MTHFR A1298C. Overall, MTHFR 677 polymorphisms were risks for IHD (TT: Risk ratio (RR) = 1.23, p < 0.0001; CT: RR = 1.04, p = 0.0028, and TT plus CT: RR = 1.09, p < 0.0001). In contrast, MTHFR 677 CC wildtype was protective against IHD (RR = 0.91, p < 0.00001) for overall populations. Three countries with elevated IHD risks from MTHFR C677T polymorphism with RR >2 included India, Turkey, and Tunisia. Meta-predictive analysis revealed that increased air pollution was associated with increased MTHFR 677 TT and CT polymorphisms in both the case and control group (p < 0.05), with the trend of increased IHD risk resulting from increased air pollution. These results associate the potential inflammatory pathway with air pollution and the folate pathway with MTHFR polymorphism. Future intervention studies can be designed to mitigate MTHFR enzyme deficiencies resulting from gene polymorphisms to prevent IHDs for at-risk populations.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
3.1
作者：
Chen, Ling;Liu, Liu;Cheng, Xiaoshu
通讯作者：
Cheng, Xiaoshu
影响因子：
120.7
作者：
Dominici, F;Peng, RD;Samet, JM
通讯作者：
Samet, JM
影响因子：
37.8
作者：
Benjamin, Emelia J.;Virani, Salim S.;Muntner, Paul
通讯作者：
Muntner, Paul