Neoadjuvant chemotherapy and less invasive surgery for the management of early stage cervical cancer: A brief report from Botswana.
Neoadjuvant chemotherapy and less invasive surgery for the management of early stage cervical cancer: A brief report from Botswana.
复制标题
DOI：
10.1016/j.gore.2022.101032
复制
发表时间：
2022-08
影响因子：
1.2
通讯作者：
Gaolebale, Ponatshego Andrew
中科院分区：
文献类型：
--
作者：
Grover, Surbhi;Luckett, Rebecca;Bhatia, Rohini K.;Ralefala, Tlotlo;Seiphetlheng, Alexander;Ramogola-Masire, Doreen;Monare, Barati;Bazzett-Matabele, Lisa;Schmeler, Kathleen;Gaolebale, Ponatshego Andrew
在无法获得妇科肿瘤医生的地区，新辅助化疗（NAC）可能是早期宫颈癌（CC）的一种治疗选择。
早期宫颈癌的新辅助化疗可使手术前肿瘤缩小。
新辅助化疗后行单纯子宫切除术的总生存期（OS）与根治性子宫切除术相当。
这种策略应在资源有限的环境中进一步研究使用。
宫颈癌导致的大多数死亡发生在中低收入国家（LMICs）。早期宫颈癌（FIGO 2018 IA2 - IB1）的标准治疗方法是根治性子宫切除术，这是由经过培训的妇科肿瘤医生实施的手术。然而，中低收入国家缺乏妇科肿瘤医生，这就需要探索早期宫颈癌的其他治疗方法。早期宫颈癌一种潜在的治疗方案是新辅助化疗后行单纯子宫切除术和盆腔淋巴结取样，这可由普通妇科医生实施。我们收集了8名接受这种治疗方法的女性的数据，发现在中位随访3.5年期间，病因特异性生存率为100%。这些发现支持在中低收入国家探索这种早期宫颈癌的治疗方法，这将改善这些女性获得治疗的机会，并有望减轻中低收入国家宫颈癌相关死亡的高负担。
In regions without access to a gynecologic oncologist, NAC may be a treatment option for early stage CC. NAC in early stage CC allows for tumor size reduction prior to surgery. NAC followed by simple hysterectomy had comparable OS to that of radical hysterectomy. This strategy should be further studied for use in limited resource settings. The majority of deaths from cervical cancer occur in low- and middle- income countries (LMICs). The standard of care for early-stage cervical cancer (FIGO 2018 IA2-IB1) is radical hysterectomy, a procedure performed by trained gynecologic oncologists. However, the lack of gynecologic oncologists in LMICs has required exploration into other methods of treatment for early-stage cervical cancer. A potential course of treatment for early-stage cervical cancer is neoadjuvant chemotherapy followed by simple hysterectomy and pelvic lymph node sampling, which can be performed by a general gynecologist. We gathered data for 8 women who underwent this method of treatment and found that cause-specific survival was 100% over a 3.5-year median follow-up. These findings support the exploration for this method of treatment for early-stage cervical cancer in LMICs, which would improve access to treatment for these women and hopefully reduce the high burden of cervical cancer related deaths in LMICs.
登录
查看更多内容
影响因子：
4.7
作者：
Rob, Lukas;Pluta, Marek;Robova, Helena
通讯作者：
Robova, Helena
影响因子：
4.8
作者：
Schmeler, Kathleen M.;Pareja, Rene;Ramirez, Pedro T.
通讯作者：
Ramirez, Pedro T.
DOI：
10.1016/s2214-109x(20)30459-9
发表时间：
2021-03
期刊：
The Lancet. Global health
影响因子：
--
作者：
Stelzle D;Tanaka LF;Lee KK;Ibrahim Khalil A;Baussano I;Shah ASV;McAllister DA;Gottlieb SL;Klug SJ;Winkler AS;Bray F;Baggaley R;Clifford GM;Broutet N;Dalal S
通讯作者：
Dalal S
影响因子：
6.2
作者：
Sullivan, Stephanie A.;Stringer, Elizabeth;Van Le, Linda
通讯作者：
Van Le, Linda
DOI：
10.1097/igc.0000000000001372
发表时间：
2018-11-01
影响因子：
4.8
作者：
Luckett, Rebecca;Kalenga, Kitenge;Grover, Surbhi
通讯作者：
Grover, Surbhi