The Central Role of Redox-Regulated Switch Proteins in Bacteria.
The Central Role of Redox-Regulated Switch Proteins in Bacteria.
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DOI：
10.3389/fmolb.2021.706039
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发表时间：
2021
影响因子：
5
通讯作者：
Reichmann D
中科院分区：
文献类型：
--
作者：
Fassler R;Zuily L;Lahrach N;Ilbert M;Reichmann D
细菌具有适应不断变化的环境的能力。为了实现这一点，细胞对关键蛋白质进行可逆的翻译后修饰，以调节它们的行为、新陈代谢、防御机制和细菌对压力的适应。在这篇综述中，我们重点介绍了在氧化应激过程中被激活的细菌蛋白开关。这种蛋白质开关是由外源性活性氧(ROS)或作为有氧生活方式副产品产生的内源性ROS触发的。硫醇开关和金属中心都被证明是ROS的主要目标。细胞利用这种反应性，将这些反应位点用作氧化还原传感器，以检测和对抗氧化应激条件。这反过来可能会诱导参与抗氧化策略的基因表达，从而保护蛋白质组免受应激条件的影响。我们进一步描述了受氧化还原开关调控的特定蛋白质的特征机制。我们重点介绍了不同交换机的机制和功能(以及共同功能)的多样性，同时还介绍了发现该系列新成员所使用的集成方法。最后，我们指出了该领域未来的挑战，包括发现新类型的交换机以及定义新的附加功能。
Bacteria possess the ability to adapt to changing environments. To enable this, cells use reversible post-translational modifications on key proteins to modulate their behavior, metabolism, defense mechanisms and adaptation of bacteria to stress. In this review, we focus on bacterial protein switches that are activated during exposure to oxidative stress. Such protein switches are triggered by either exogenous reactive oxygen species (ROS) or endogenous ROS generated as by-products of the aerobic lifestyle. Both thiol switches and metal centers have been shown to be the primary targets of ROS. Cells take advantage of such reactivity to use these reactive sites as redox sensors to detect and combat oxidative stress conditions. This in turn may induce expression of genes involved in antioxidant strategies and thus protect the proteome against stress conditions. We further describe the well-characterized mechanism of selected proteins that are regulated by redox switches. We highlight the diversity of mechanisms and functions (as well as common features) across different switches, while also presenting integrative methodologies used in discovering new members of this family. Finally, we point to future challenges in this field, both in uncovering new types of switches, as well as defining novel additional functions.
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影响因子：
3.2
作者：
Fuangthong, M;Herbig, AF;Helmann, JD
通讯作者：
Helmann, JD
DOI：
10.1073/pnas.0609514104
发表时间：
2007-02-13
影响因子：
11.1
作者：
Crack, Jason C.;Green, Jeffrey;Thomson, Andrew J.
通讯作者：
Thomson, Andrew J.
影响因子：
1.2
作者：
Fassler, Rosi;Edinger, Nufar;Reichmann, Dana
通讯作者：
Reichmann, Dana
影响因子：
46.9
作者：
通讯作者：
--
影响因子：
20.1
作者：
Chung HS;Wang SB;Venkatraman V;Murray CI;Van Eyk JE
通讯作者：
Van Eyk JE