Long-term immunity to measles, mumps, and rubella after allogeneic bone marrow transplantation.
Long-term immunity to measles, mumps, and rubella after allogeneic bone marrow transplantation.
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异体骨髓移植后对麻疹、腮腺炎、风疹具有长期免疫力。
DOI：
10.1182/blood.v84.2.657.657
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发表时间：
1994
期刊：
影响因子：
20.3
通讯作者：
G. Gahrton
中科院分区：
文献类型：
--
作者：
P. Ljungman;Ilona Lewensohn;V. Hammarström;J. Aschan;L. Brandt;Per Bolme;Berit Lönnqvist;Nina Johansson;Olle Ringdén;G. Gahrton
共有124名患者在异基因骨髓移植(BMT)后存活至少2年。每年至少采集一次血清。用酶联免疫吸附试验检测麻疹、流行性腮腺炎的抗体。风疹抗体检测采用放射状溶血法。抗体水平被解释为代表免疫力、血清阴性或血清阳性，但免疫力不确定。中位随访期为6.5年(2~13.5年)。BMT后3、5和7年对麻疹免疫的计算概率分别为47%、27%和20%。腮腺炎的相应概率分别为37%、12%和6%；风疹的相应概率分别为47%、33%和28%。骨髓移植后5年麻疹、腮腺炎和风疹血清阴性的概率分别为60%、73%和52%。与既往有自然麻疹病史(P<；0.05)的患者相比，影响BMT后麻疹免疫的唯一重要因素是患者是否在BMT前接种过疫苗。在随访期间，供者的血清阳性对腮腺炎血清阴性的概率没有影响。我们的结论是，大多数异基因患者在随访期间会出现麻疹、腮腺炎和风疹的血清阴性。因此，无论捐赠者的免疫状态如何，长期的B细胞记忆功能都不会保持。
A total of 124 patients who had survived at least 2 years after allogeneic bone marrow transplantation (BMT) were studied. Serum was collected at least once yearly. IgG antibodies were determined by enzyme-linked immunosorbent assay for measles and mumps. Rubella antibodies were analyzed by radial hemolysis. Antibody levels were interpreted as representing immunity, seronegativity, or seropositivity, but with uncertain immunity. The median follow-up of the patients was 6.5 years (range, 2 to 13.5 years). The calculated probabilities of being immune to measles at 3, 5, and 7 years from BMT were 47%, 27%, and 20%, respectively. The corresponding probabilities for mumps were 37%, 12%, and 6%, respectively; and for rubella, 47%, 33%, and 28%, respectively. The probabilities for being seronegative for measles, mumps, and rubella at 5 years after BMT were 60%, 73%, and 52%, respectively. When compared with those patients who had experienced previous natural measles disease (P < .05), the only factor that was important for immunity to measles after BMT was whether the patient had been immunized before BMT. There was no influence of donor seropositivity on the probability of becoming seronegative to mumps during follow-up. We conclude that most allogeneic patients will become seronegative to measles, mumps, and rubella during follow-up. Therefore, long-term B-cell memory function is not maintained, regardless of the immune status of the donor.
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DOI：
--
发表时间：
1982
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Lum,LG;Orcutt-Thordarson,N;Seigneuret,MC;Storb,R
通讯作者：
Storb,R
DOI：
10.1172/jci112686
发表时间：
1986
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Saxon,A;Mitsuyasu,R;Stevens,R;Champlin,RE;Kimata,H;Gale,RP
通讯作者：
Gale,RP
检测人骨髓移植后记忆抗原的特异性抗体形成。
影响因子：
20.3
作者：
Lum,LG;Munn,NA;Schanfield,MS;Storb,R
通讯作者：
Storb,R
在接受 HLA 不匹配、T 细胞耗尽或 HLA 相同骨髓移植的骨髓受者中转移特异性免疫。
影响因子：
4.8
作者：
Lum,LG;Noges,JE;Beatty,P;Martin,PJ;Deeg,J;Doney,KC;Loughran,T;Sullivan,KM;Witherspoon,RP;Thomas,ED
通讯作者：
Thomas,ED