TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.
TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.
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TRIM37 有助于胃癌的恶性结果和 CDDP 耐药性。
DOI：
10.7150/jca.47577
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发表时间：
2021
影响因子：
3.9
通讯作者：
Otsuji E
中科院分区：
文献类型：
--
作者：
Nishibeppu K;Komatsu S;Kiuchi J;Kishimoto T;Takashima Y;Shoda K;Arita T;Kosuga T;Konishi H;Shiozaki A;Kubota T;Okamoto K;Fujiwara H;Tsuda H;Otsuji E
背景：TRIM37 （Tripartite Motif Containing 37）是组蛋白H2A的E3泛素连接酶，可抑制多种基因的转录。然而，它是否在胃癌（GC）中起作用尚不清楚。在本研究中，我们通过在GC中过表达来检测TRIM37是否作为促癌因子。方法：对我院2001 ~ 2003年治愈切除的124例胃癌细胞系和原发肿瘤进行分析。结果：TRIM37蛋白在几乎所有胃癌细胞系和胃癌标本中（124例中有76例）均有过表达，且与淋巴和静脉浸润、t期、n期晚期、组织学及高复发率显著相关。TRIM37过表达肿瘤患者的生存率低于非表达肿瘤患者（P=0.0057）。此外，TRIM37阳性被确定为预测较差结局的独立因素（P=0.018，风险比3.41）。凋亡细胞分析显示，与对照组相比，敲低TRIM37使细胞凋亡增加。在过表达TRIM37的GC细胞中，敲低TRIM37可抑制其迁移和侵袭。结论：TRIM37通过其过表达在肿瘤恶性潜能中起着至关重要的作用，突出了其作为胃癌预后因素和潜在治疗靶点的作用。
Background: TRIM37 (Tripartite Motif Containing 37) is an E3 ubiquitin ligase for histone H2A and inhibits transcription in several genes. However, it is not known whether it plays a role in gastric cancer (GC). In this study, we tested whether TRIM37 acts as a cancer-promoting factor by being overexpressed in GC. Methods: We analyzed GC cell lines and 124 primary tumors, which were curatively resected in our hospital between 2001 and 2003. Results: Overexpression of the TRIM37 protein was detected in almost all GC cell lines and GC samples (76 out of 124 cases) and was significantly correlated with lymphatic and venous invasion, advanced T-Stage, N-Stage, histology and high recurrence rate. Patients with TRIM37 overexpressing tumors had a worse survival rate than those with non-expressing tumors (P=0.0057). Moreover, TRIM37 positivity was identified as an independent factor predicting worse outcomes (P=0.018, Hazard ratio 3.41). The apoptotic cell analysis showed that the knockdown of TRIM37 increased apoptosis in comparison with the control. In TRIM37 overexpressing GC cells, knockdown of TRIM37 suppressed the migration and invasion. Conclusions: TRIM37 plays a crucial role in tumor malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in GC.
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影响因子：
8.8
作者：
Komatsu S;Ichikawa D;Hirajima S;Nagata H;Nishimura Y;Kawaguchi T;Miyamae M;Okajima W;Ohashi T;Konishi H;Shiozaki A;Fujiwara H;Okamoto K;Tsuda H;Imoto I;Inazawa J;Otsuji E
通讯作者：
Otsuji E
影响因子：
7.3
作者：
MAESAWA, C;TAMURA, G;SATODATE, R
通讯作者：
SATODATE, R
影响因子：
4.3
作者：
Fang, DC;Wang, RQ;Luo, YH
通讯作者：
Luo, YH
DOI：
10.1038/nrc2931
发表时间：
2010-10
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1016/s0140-6736(09)60617-6
发表时间：
2009-08-08
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hartgrink HH;Jansen EP;van Grieken NC;van de Velde CJ
通讯作者：
van de Velde CJ