Duloxetine, a Selective Noradrenaline Reuptake Inhibitor, Increased Plasma Levels of 3-Methoxy-4-hydroxyphenylglycol but Not Homovanillic Acid in Patients with Major Depressive Disorder.
Duloxetine, a Selective Noradrenaline Reuptake Inhibitor, Increased Plasma Levels of 3-Methoxy-4-hydroxyphenylglycol but Not Homovanillic Acid in Patients with Major Depressive Disorder.
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DOI：
10.9758/cpn.2014.12.1.37
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Nakamura J
中科院分区：
文献类型：
--
作者：
Atake K;Yoshimura R;Hori H;Katsuki A;Ikenouchi-Sugita A;Umene-Nakano W;Nakamura J
我们研究了度洛沙汀对64例抑郁症患者血浆中儿茶酚胺代谢产物和血清脑源性神经营养因子（BDNF）水平的影响。根据DSM-IV文本修订版（DSM-IV-TR）标准，使用精神疾病诊断与统计手册第四版（DSM-IV）的结构化临床访谈诊断重度抑郁发作。采用17项汉密尔顿抑郁量表（HAMD-17）评定抑郁的严重程度。在第0、28和56天进行血液采样和临床评价。度洛沙汀治疗8周显著增加MDD应答者的血浆3-甲氧基-4-羟基苯乙二醇（MHPG）水平，但不增加高香草酸（HVA）水平。这些结果表明，去甲肾上腺素在缓解抑郁症状中起着重要作用。
We investigated the effects of duloxetine on the plasma levels of catecholamine metabolites and serum brain-derived neurotrophic factor (BDNF) in 64 patients with major depressive disorder (MDD). Major depressive episode was diagnosed using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-fourth edition (DSM-IV) according to the DSM-IV text revision (DSM-IV-TR) criteria. The severity of depression was evaluated using the 17-item Hamilton Rating Scale for Depression (HAMD-17). Blood sampling and clinical evaluation were performed on days 0, 28, and 56. Duloxetine treatment for 8 weeks significantly increased the plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels but not the homovanillic acid (HVA) levels in responders with MDD. These results imply that noradrenaline plays an important role in alleviating depressive symptoms.
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影响因子：
3.3
作者：
Katsuki, Asuka;Yoshimura, Reiji;Nakamura, Jun
通讯作者：
Nakamura, Jun
影响因子：
10.6
作者：
Sen, Srijan;Duman, Ronald;Sanacora, Gerard
通讯作者：
Sanacora, Gerard
影响因子：
2.9
作者：
Shinkai, K;Yoshimura, R;Nakamura, J
通讯作者：
Nakamura, J
影响因子：
3.1
作者：
Bocchio-Chiavetto, Luisella;Bagnardi, Vincenzo;Gennarelli, Massimo
通讯作者：
Gennarelli, Massimo
影响因子：
7.6
作者：
Chalon, SA;Granier, LA;Potter, WZ
通讯作者：
Potter, WZ