Prolonged reduction of motion sickness sensitivity by visual-vestibular interaction.
Prolonged reduction of motion sickness sensitivity by visual-vestibular interaction.
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DOI：
10.1007/s00221-011-2548-8
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发表时间：
2011-05
影响因子：
2
通讯作者：
Cohen, Bernard
中科院分区：
文献类型：
--
作者：
Dai, Mingjia;Raphan, Ted;Cohen, Bernard
关键词：
本研究采用低频同时诱发前庭眼角反射（aVOR）和视动性眼震（OKN）的方法，研究前庭系统速度储存时间常数的习惯化对运动病的影响。29名受试者（其中11名易受普通交通工具的晕动病影响）习惯于以0.017 Hz的正弦旋转，峰值速度从5 °/s到20°/s，同时观看全场OKN刺激。OKN条纹以与受试者相同的方向和频率旋转，但速度更高。这产生了与aVOR反应方向相反的OKN。运动病的敏感性进行了评估与偏离垂直轴旋转（OVAR）和运输之前和之后5天的视觉前庭习惯的反应。习惯化并没有引起运动病或改变aVOR增益，但它缩短了所有受试者的前庭时间常数。这大大降低了OVAR产生的运动病和对运动敏感受试者中常见运输的敏感性，这些症状持续长达18周。两名仅具有aVOR/OKN习惯性而未进行OVAR测试的运动易感受试者也变得无症状。未习惯的正常受试者的aVOR时间常数或运动病敏感性均未降低。相反的aVOR/OKN刺激，以前没有研究过，耐受性良好，并且第一次是一种快速和长期习惯性晕动病的有效技术，而无需暴露于药物或其他刺激习惯性刺激。
The angular vestibulo-ocular reflex (aVOR) and optokinetic nystagmus (OKN) were elicited simultaneously at low frequencies to study effects of habituation of the velocity storage time constant in the vestibular system on motion sickness. Twenty-nine subjects, eleven of whom were susceptible to motion sickness from common transportation, were habituated by sinusoidal rotation at 0.017 Hz at peak velocities from 5 to 20°/s, while they watched a full-field OKN stimulus. The OKN stripes rotated in the same direction and at the same frequency as the subjects, but at a higher velocity. This produced an OKN opposite in direction to the aVOR response. Motion sickness sensitivity was evaluated with off-vertical axis rotation (OVAR) and by the response to transportation before and after 5 days of visual-vestibular habituation. Habituation did not induce motion sickness or change the aVOR gains, but it shortened the vestibular time constants in all subjects. This greatly reduced motion sickness produced by OVAR and sensitivity to common transport in the motion susceptible subjects, which persisted for up to 18 weeks. Two motion susceptible subjects who only had aVOR/OKN habituation without being tested with OVAR also became asymptomatic. Normal subjects who were not habituated had no reduction in either their aVOR time constants or motion sickness sensitivity. The opposing aVOR/OKN stimulation, which has not been studied before, was well tolerated, and for the first time was an effective technique for rapid and prolonged habituation of motion sickness without exposure to drugs or other nauseating habituation stimuli.
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DOI：
10.1111/j.1749-6632.1981.tb30888.x
发表时间：
1981-01-01
影响因子：
5.2
作者：
COHEN, B;HENN, V;DENNETT, D
通讯作者：
DENNETT, D
影响因子：
2
作者：
Clement, Gilles;Tilikete, Caroline;Courjon, Jean-Hubert
通讯作者：
Courjon, Jean-Hubert
影响因子：
3.8
作者：
Guedry, FE;Rupert, AR;Reschke, MF
通讯作者：
Reschke, MF
影响因子：
3.5
作者：
GRAYBIEL, A;MILLER, EF;HOMICK, JL
通讯作者：
HOMICK, JL
影响因子：
2.5
作者：
DAI, MJ;RAPHAN, T;COHEN, B
通讯作者：
COHEN, B