The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia.
The Complement of Projection Neurons Activated Determines the Type of Feeding Motor Program in Aplysia.
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DOI：
10.3389/fncir.2021.685222
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发表时间：
2021
影响因子：
3.5
通讯作者：
Cropper EC
中科院分区：
文献类型：
--
作者：
Evans CG;Barry MA;Jing J;Perkins MH;Weiss KR;Cropper EC
多个投射神经元经常被激活来启动行为。随之而来的一个问题是，每个被激活的神经元的独特功能是什么？我们在海兔的饲养系统中解决了这个问题。以前的实验发现了一种投射神经元[脑颊中间神经元2(CBI-2)]，它可以触发摄食运动程序，但只有在重复刺激后才能触发，即初始程序定义不清。随着CBI-2刺激的继续，程序逐渐变得更容易摄取(重复启动发生)。这种启动的结果，至少部分是由于CBI-2释放的多肽共递质的持续作用。我们现在证明，在一些准备中，重复启动不会发生。没有明显的季节性效应；全年都会遇到引爆和非引爆准备。CBI-2与第二个投射神经元--脑颊中间神经元3(CBI-3)电耦合。在没有发生启动的制剂中，我们证明了当CBI-2和CBI-3被共同激活时，就会产生摄取活动。程序是立即摄取的，也就是说，启动是不必要的，并且不会诱导持续状态。我们的数据表明，活动结构的动态变化可以改变，并由触发活动的投射神经元的补充决定。
Multiple projection neurons are often activated to initiate behavior. A question that then arises is, what is the unique functional role of each neuron activated? We address this issue in the feeding system of Aplysia. Previous experiments identified a projection neuron [cerebral buccal interneuron 2 (CBI-2)] that can trigger ingestive motor programs but only after it is repeatedly stimulated, i.e., initial programs are poorly defined. As CBI-2 stimulation continues, programs become progressively more ingestive (repetition priming occurs). This priming results, at least in part, from persistent actions of peptide cotransmitters released from CBI-2. We now show that in some preparations repetition priming does not occur. There is no clear seasonal effect; priming and non-priming preparations are encountered throughout the year. CBI-2 is electrically coupled to a second projection neuron, cerebral buccal interneuron 3 (CBI-3). In preparations in which priming does not occur, we show that ingestive activity is generated when CBI-2 and CBI-3 are coactivated. Programs are immediately ingestive, i.e., priming is not necessary, and a persistent state is not induced. Our data suggest that dynamic changes in the configuration of activity can vary and be determined by the complement of projection neurons that trigger activity.
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影响因子：
2.5
作者：
Koh, Hae-Young;Weiss, Klaudiusz R.
通讯作者：
Weiss, Klaudiusz R.
影响因子：
16.2
作者：
Bidaye, Salil S.;Laturney, Meghan;Chang, Amy K.;Liu, Yuejiang;Bockemuehl, Till;Bueschges, Ansgar;Scott, Kristin
通讯作者：
Scott, Kristin
DOI：
10.1523/jneurosci.1287-10.2010
发表时间：
2010-06-30
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Friedman AK;Weiss KR
通讯作者：
Weiss KR
DOI：
10.1007/bf00214712
发表时间：
1993-02-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
影响因子：
--
作者：
MORTON, DW;CHIEL, HJ
通讯作者：
CHIEL, HJ
DOI：
10.1073/pnas.0402002101
发表时间：
2004-06-22
影响因子：
11.1
作者：
Proekt, A;Brezina, V;Weiss, KR
通讯作者：
Weiss, KR