Bone morphogenetic protein signaling in vertebrate motor neurons and neuromuscular communication.

Bone morphogenetic protein signaling in vertebrate motor neurons and neuromuscular communication.
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DOI:
10.3389/fncel.2014.00453
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发表时间:
2014
影响因子:
5.3
通讯作者:
Henríquez JP
Henríquez JP
中科院分区:
医学2区
文献类型:
--
作者:
Osses N;Henríquez JP

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运动神经元和骨骼肌纤维之间的准确通信是神经肌肉接头 (NMJ) 正确组装、生长和维护所必需的。几种信号传导和细胞外基质分子对功能性突触的组装发挥刺激和抑制作用。对果蝇的研究揭示了早期形态发生素(例如 Wnt 和骨形态发生蛋白 (BMP) 信号通路成员)在 NMJ 组装和成熟过程中的关键功能。在这里,我们汇集了最新的发现,这些发现使我们提出 BMP 也可以在脊椎动物中作为运动神经元和骨骼肌通讯的扩散线索。
An accurate communication between motor neurons and skeletal muscle fibers is required for the proper assembly, growth and maintenance of neuromuscular junctions (NMJs). Several signaling and extracellular matrix molecules play stimulatory and inhibitory roles on the assembly of functional synapses. Studies in Drosophila have revealed crucial functions for early morphogens, such as members of the Wnt and Bone Morphogenetic Proteins (BMP) signaling pathways, during the assembly and maturation of the NMJ. Here, we bring together recent findings that led us to propose that BMPs also work in vertebrate organisms as diffusible cues to communicate motor neurons and skeletal muscles.
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