Cohort profile: A Prospective Household cohort study of Influenza, Respiratory syncytial virus and other respiratory pathogens community burden and Transmission dynamics in South Africa, 2016-2018.
Cohort profile: A Prospective Household cohort study of Influenza, Respiratory syncytial virus and other respiratory pathogens community burden and Transmission dynamics in South Africa, 2016-2018.
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DOI：
10.1111/irv.12881
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发表时间：
2021-11
影响因子：
4.4
通讯作者：
PHIRST group
中科院分区：
文献类型：
--
作者：
Cohen C;McMorrow ML;Martinson NA;Kahn K;Treurnicht FK;Moyes J;Mkhencele T;Hellferscee O;Lebina L;Moroe M;Motlhaoleng K;Gómez-Olivé FX;Wagner R;Tollman S;Wafawanaka F;Ngobeni S;Kleynhans J;Mathunjwa A;Buys A;Maake L;Wolter N;Carrim M;Piketh S;Language B;Mathee A;von Gottberg A;Tempia S;PHIRST group
PHIRST研究（南非流感、呼吸道合胞病毒和其他呼吸道病原体社区负担和传播动态的前瞻性家庭队列研究）旨在估计流感和呼吸道合胞病毒（RSV）的社区负担，包括感染发生率、症状分数，并评估家庭传播。我们在农村和城市地区的327个随机选择的家庭中招募了1684名个体，这些家庭连续三个流感季节和两个RSV季节。每年都有一批新的家庭登记。在入组当年的RSV和流感季节，每周两次对受试者进行鼻咽拭子采样。在入组时以及每年流感季节前后采集血清学样本。3年内有122113次潜在的个人随访，其中105783（87%）例参与者接受了采访。在105683份鼻咽拭子中，分别有1258份（1%）和1026份（1%）的流感病毒和RSV聚合酶链反应（PCR）检测结果呈阳性。每年有超过三分之一的人患有PCR确认的流感。总体而言，流感传播到10%的指示病例的家庭接触者。未来计划的分析包括流感血清学结果和RSV负荷和传播分析。在2016-2018年期间参加PHIRST研究的家庭有资格参加2020年7月开始的SARS-CoV-2传播研究。该研究使用类似的检测频率来评估SARS-CoV-2感染的社区负担以及无症状感染在病毒传播中的作用。
The PHIRST study (Prospective Household cohort study of Influenza, Respiratory Syncytial virus, and other respiratory pathogens community burden and Transmission dynamics in South Africa) aimed to estimate the community burden of influenza and respiratory syncytial virus (RSV) including the incidence of infection, symptomatic fraction, and to assess household transmission. We enrolled 1684 individuals in 327 randomly selected households in a rural and an urban site over three consecutive influenza and two RSV seasons. A new cohort of households was enrolled each year. Participants were sampled with nasopharyngeal swabs twice‐weekly during the RSV and influenza seasons of the year of enrolment. Serology samples were collected at enrolment and before and after the influenza season annually. There were 122 113 potential individual follow‐up visits over the 3 years, and participants were interviewed for 105 783 (87%) of these. Out of 105 683 nasopharyngeal swabs, 1258 (1%) and 1026 (1%) tested positive on polymerase chain reaction (PCR) for influenza viruses and RSV, respectively. Over one third of individuals had PCR‐confirmed influenza each year. Overall, there was influenza transmission to 10% of household contacts of an index case. Future planned analyses include analysis of influenza serology results and RSV burden and transmission. Households enrolled in the PHIRST study during 2016–2018 were eligible for inclusion in a study of SARS‐CoV‐2 transmission initiated in July 2020. This study uses similar testing frequency to assess the community burden of SARS‐CoV‐2 infection and the role of asymptomatic infection in virus transmission.
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DOI：
10.1016/s0140-6736(18)32203-7
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Causes of Death Collaborators
通讯作者：
GBD 2017 Causes of Death Collaborators
影响因子：
9.4
作者：
Hu, AZ;Colella, M;Cheng, SM
通讯作者：
Cheng, SM
影响因子：
11.8
作者：
Jernigan, D. B.;Lindstrom, S. L.;Shaw, M. W.
通讯作者：
Shaw, M. W.
DOI：
10.1016/s0140-6736(17)30938-8
发表时间：
2017-09-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Shi T;McAllister DA;O'Brien KL;Simoes EAF;Madhi SA;Gessner BD;Polack FP;Balsells E;Acacio S;Aguayo C;Alassani I;Ali A;Antonio M;Awasthi S;Awori JO;Azziz-Baumgartner E;Baggett HC;Baillie VL;Balmaseda A;Barahona A;Basnet S;Bassat Q;Basualdo W;Bigogo G;Bont L;Breiman RF;Brooks WA;Broor S;Bruce N;Bruden D;Buchy P;Campbell S;Carosone-Link P;Chadha M;Chipeta J;Chou M;Clara W;Cohen C;de Cuellar E;Dang DA;Dash-Yandag B;Deloria-Knoll M;Dherani M;Eap T;Ebruke BE;Echavarria M;de Freitas Lázaro Emediato CC;Fasce RA;Feikin DR;Feng L;Gentile A;Gordon A;Goswami D;Goyet S;Groome M;Halasa N;Hirve S;Homaira N;Howie SRC;Jara J;Jroundi I;Kartasasmita CB;Khuri-Bulos N;Kotloff KL;Krishnan A;Libster R;Lopez O;Lucero MG;Lucion F;Lupisan SP;Marcone DN;McCracken JP;Mejia M;Moisi JC;Montgomery JM;Moore DP;Moraleda C;Moyes J;Munywoki P;Mutyara K;Nicol MP;Nokes DJ;Nymadawa P;da Costa Oliveira MT;Oshitani H;Pandey N;Paranhos-Baccalà G;Phillips LN;Picot VS;Rahman M;Rakoto-Andrianarivelo M;Rasmussen ZA;Rath BA;Robinson A;Romero C;Russomando G;Salimi V;Sawatwong P;Scheltema N;Schweiger B;Scott JAG;Seidenberg P;Shen K;Singleton R;Sotomayor V;Strand TA;Sutanto A;Sylla M;Tapia MD;Thamthitiwat S;Thomas ED;Tokarz R;Turner C;Venter M;Waicharoen S;Wang J;Watthanaworawit W;Yoshida LM;Yu H;Zar HJ;Campbell H;Nair H;RSV Global Epidemiology Network
通讯作者：
RSV Global Epidemiology Network
DOI：
10.1016/s2214-109x(18)30247-x
发表时间：
2018-07
期刊：
The Lancet. Global health
影响因子：
--
作者：
Wahl B;O'Brien KL;Greenbaum A;Majumder A;Liu L;Chu Y;Lukšić I;Nair H;McAllister DA;Campbell H;Rudan I;Black R;Knoll MD
通讯作者：
Knoll MD