Cerebral blood flow with [15O]water PET studies using an image-derived input function and MR-defined carotid centerlines.
Cerebral blood flow with [15O]water PET studies using an image-derived input function and MR-defined carotid centerlines.
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DOI：
10.1088/0031-9155/58/6/1903
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发表时间：
2013-03-21
影响因子：
3.5
通讯作者：
Carson RE
中科院分区：
文献类型：
--
作者：
Fung EK;Carson RE
脑PET数据的完全定量分析需要了解动脉输入脑的功能。这些数据通常是通过动脉采样获得的，并对延迟和分散进行校正，以考虑到遥远的采样地点。已经进行了几次尝试来直接从供应大脑并且通常在大脑PET图像中可见的颈内动脉提取图像导出的输入函数（IDIF）。我们已经设计了一种方法，划定内颈动脉共注册的MR图像使用水平集方法和应用分割PET图像使用一种新的中心线的方法。分割的颈动脉的中心线被建模为三次样条，并在扫描早期部分的PET图像中重新配准。使用来自血管解剖中心的信息应尽量减少部分容积和溢出效应。中心线时间-活动曲线取为沿着从相邻体素内插的中心线的点的值的平均值。使用金标准动脉血测量值计算脑血流量（CBF）得出比例因子校正。我们已经将该方法应用于人类受试者的数据从[15 O]水的多次注射的HRT。通过计算IDIF和CBF的曲线下面积（AUC），并将其与使用金标准动脉输入曲线计算的值进行比较，对该方法进行评估。9例多次注射受试者（n = 69）的IDIF与动脉AUC的平均比值（表观回收系数：aRC）在示踪剂到达后0-30 s为0.49 ± 0.09，30-60 s为0.45 ± 0.09，60-90 s为0.46 ± 0.09。使用采集的血液数据，灰质和白色物质CBF值分别为61.4 ± 11.0和15.6 ± 3.0 mL/min/100 g组织。使用IDIF中心线，通过每个受试者注射的平均aRC进行缩放，灰质和白色CBF值分别为61.3 ± 13.5和15.5 ± 3.4 mL/min/100 g组织。使用总体平均aRC值，平均值不变，受试者间变异性显著降低。这种基于MR的中心线方法与[15 O]水PET的局部重新配准在同一受试者的多次注射中产生一致的IDIF，从而允许在没有动脉输入功能测量的情况下对CBF进行绝对定量。
Full quantitative analysis of brain PET data requires knowledge of the arterial input function into the brain. Such data are normally acquired by arterial sampling with corrections for delay and dispersion to account for the distant sampling site. Several attempts have been made to extract an image-derived input function (IDIF) directly from the internal carotid arteries that supply the brain and are often visible in brain PET images. We have devised a method of delineating the internal carotids in co-registered MR images using the level-set method and applying the segmentations to PET images using a novel centerline approach. Centerlines of the segmented carotids were modeled as cubic splines and re-registered in PET images summed over the early portion of the scan. Using information from the anatomical center of the vessel should minimize partial volume and spillover effects. Centerline time-activity curves were taken as the mean of the values for points along the centerline interpolated from neighboring voxels. A scale factor correction was derived from calculation of cerebral blood flow (CBF) using gold standard arterial blood measurements. We have applied the method to human subject data from multiple injections of [15O]water on the HRRT. The method was assessed by calculating the area under the curve (AUC) of the IDIF and the CBF, and comparing these to values computed using the gold standard arterial input curve. The average ratio of IDIF to arterial AUC (apparent recovery coefficient: aRC) across 9 subjects with multiple (n = 69) injections was 0.49 ± 0.09 at 0–30 s post tracer arrival, 0.45 ± 0.09 at 30–60 s, and 0.46 ± 0.09 at 60–90 s. Grey and white matter CBF values were 61.4 ± 11.0 and 15.6 ± 3.0 mL/min/100g tissue using sampled blood data. Using IDIF centerlines scaled by the average aRC over each subjects’ injections, gray and white matter CBF values were 61.3 ± 13.5 and 15.5 ± 3.4 mL/min/100g tissue. Using global average aRC values, the means were unchanged, and intersubject variability was noticeably reduced. This MR-based centerline method with local re-registration to [15O]water PET yields a consistent IDIF over multiple injections in the same subject, thus permitting the absolute quantification of CBF without arterial input function measurements.
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DOI：
10.1007/s00259-010-1443-z
发表时间：
2010-08
影响因子：
9.1
作者：
Croteau, Etienne;Lavallee, Eric;Labbe, Sebastien M.;Hubert, Laurent;Pifferi, Fabien;Rousseau, Jacques A.;Cunnane, Stephen C.;Carpentier, Andre C.;Lecomte, Roger;Benard, Francois
通讯作者：
Benard, Francois
影响因子：
10.6
作者：
Chan, TF;Vese, LA
通讯作者：
Vese, LA
DOI：
10.1007/s002590000405
发表时间：
2001-01-01
期刊：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
影响因子：
--
作者：
Boellaard, R;van Lingen, A;Lammertsma, AA
通讯作者：
Lammertsma, AA
影响因子：
3.5
作者：
de Jong, Hugo W. A. M.;van Velden, Floris H. P.;Lammertsma, Adriaan A.
通讯作者：
Lammertsma, Adriaan A.
影响因子：
3.5
作者：
Asselin, MC;Cunningham, VJ;Nahmias, C
通讯作者：
Nahmias, C