Associations of Perceived Stress and Psychological Resilience With Cognition and a Modifiable Dementia Risk Score in Middle-Aged Adults.
Associations of Perceived Stress and Psychological Resilience With Cognition and a Modifiable Dementia Risk Score in Middle-Aged Adults.
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DOI：
10.1093/geronb/gbad131
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发表时间：
2023-12-06
影响因子：
6.2
通讯作者：
Pase, Matthew P.
中科院分区：
文献类型：
--
作者：
Franks, Katherine H.;Bransby, Lisa;Cribb, Lachlan;Buckley, Rachel;Yassi, Nawaf;Chong, Trevor T-J;Saling, Michael M.;Lim, Yen Ying;Pase, Matthew P.
心理压力被认为是认知障碍和痴呆症的危险因素。然而，目前还不清楚一个人的压力应对能力（即，心理弹性）与认知有关。这项横断面研究调查了感知压力和心理弹性是否与认知和可修改的痴呆症风险评分在一个大的社区为基础的样本认知正常的成年人。心理弹性的调节作用也进行了研究。参加基于网络的健康大脑项目的参与者（平均年龄= 57 ± 7岁）完成了感知压力量表和Connor-Davidson弹性量表。使用Cogstate Brief Battery（n = 1，709）评估注意力和工作记忆领域，使用剑桥神经心理测试自动组合（n = 1，522）评估联想记忆。使用修改后的心血管风险因素、衰老和痴呆风险评分的发生率估计了1，913名参与者的痴呆风险，仅使用易于修改的痴呆风险因素计算。在调整年龄，性别，教育和种族的单独线性回归分析中，更高水平的感知压力和更低水平的心理弹性与所有认知领域的表现较差以及更高的可修改痴呆风险评分相关。心理弹性没有缓和感知压力对认知或痴呆风险评分的影响。较高的压力感知和较低的弹性与认知能力较差和可改变的痴呆风险因素的负担更大有关。需要进行干预研究，以确定降低压力和建立弹性是否可以减轻认知缺陷并降低痴呆风险。
Psychological stress has been proposed as a risk factor for cognitive impairment and dementia. However, it remains unclear how an individual’s stress-coping ability (i.e., psychological resilience) is related to cognition. This cross-sectional study investigated whether perceived stress and psychological resilience were associated with cognition and a modifiable dementia risk score in a large community-based sample of cognitively normal adults. The moderating effect of psychological resilience was also examined. Participants (mean age = 57 ± 7 years) enrolled in the web-based Healthy Brain Project completed the Perceived Stress Scale and the Connor–Davidson Resilience Scale. Domains of attention and working memory were assessed using the Cogstate Brief Battery (n = 1,709), and associative memory was assessed using the Cambridge Neuropsychological Test Automated Battery (n = 1,522). Dementia risk was estimated for 1,913 participants using a modified version of the Cardiovascular Risk Factors, Aging, and Incidence of Dementia dementia risk score, calculated using only readily modifiable dementia risk factors. In separate linear regression analyses adjusted for age, sex, education, and race, greater levels of perceived stress and lower levels of psychological resilience were associated with poorer performance across all cognitive domains, as well as a higher modifiable dementia risk score. Psychological resilience did not moderate the effect of perceived stress on cognition or the dementia risk score. Higher perceived stress and lower resilience were associated with poorer cognition and a greater burden of modifiable dementia risk factors. Intervention studies are required to determine if lowering stress and building resilience can mitigate cognitive deficits and reduce dementia risk.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
精神分裂症和双相情感障碍患者以及健康对照者的适应能力和认知功能
影响因子：
4.7
作者：
Deng M;Pan Y;Zhou L;Chen X;Liu C;Huang X;Tao H;Pu W;Wu G;Hu X;He Z;Xue Z;Liu Z;Rosenheck R
通讯作者：
Rosenheck R
影响因子：
7.4
作者：
Connor, KM;Davidson, JRT
通讯作者：
Davidson, JRT
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
4
作者：
Lim, Yen Ying;Yassi, Nawaf;Buckley, Rachel
通讯作者：
Buckley, Rachel