Resilience and Cognitive Function in Patients With Schizophrenia and Bipolar Disorder, and Healthy Controls.
Resilience and Cognitive Function in Patients With Schizophrenia and Bipolar Disorder, and Healthy Controls.
复制标题
精神分裂症和双相情感障碍患者以及健康对照者的适应能力和认知功能
DOI：
10.3389/fpsyt.2018.00279
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发表时间：
2018
影响因子：
4.7
通讯作者：
Rosenheck R
中科院分区：
文献类型：
--
作者：
Deng M;Pan Y;Zhou L;Chen X;Liu C;Huang X;Tao H;Pu W;Wu G;Hu X;He Z;Xue Z;Liu Z;Rosenheck R
背景：本研究比较了精神分裂症患者、双相情感障碍患者和健康对照者的适应性韧性，并检验了韧性与认知功能的关系。
方法：81名被诊断为精神分裂症的患者、34名双相情感障碍患者和52名健康对照者完成了康纳 - 戴维森韧性量表（CD - RISC）以及言语理解、执行功能和工作记忆的认知测试。对诊断组在CD - RISC和认知测试方面进行了配对比较。采用线性回归来确定临床诊断和神经认知与韧性缺陷的独立关联。
结果：两个患者组的CD - RISC得分均显著低于健康对照组，认知功能也较差，并且精神分裂症组在这些指标上的得分也低于双相情感障碍组。在整个样本中，CD - RISC得分与所有三项认知指标呈正相关，但在诊断亚组内无此相关性。多元回归分析表明，诊断组之间CD - RISC的差异并非由这三项神经认知指标的差异所介导。
讨论：精神分裂症和双相情感障碍与韧性和认知功能的损害均有关，但韧性的损害似乎与此处所测的认知功能缺陷无关，可能反映了未测量的认知功能维度、其他损害或环境因素。
Background: This study compared adaptive resilience among patients with schizophrenia, bipolar disorder, and healthy controls, and examined the relationship of resilience to cognitive function. Methods: A sample of 81 patients diagnosed with schizophrenia, 34 with bipolar disorder, and 52 healthy controls completed the Connor-Davidson Resilience Scale (CD-RISC) and cognitive tests of verbal comprehension, executive functioning, and working memory. Paired comparison of diagnostic groups on CD-RISC and cognitive tests was conducted. Linear regression was used to identify the independent association of clinical diagnoses and neurocognition with resilience deficits. Results: Both patient groups showed significantly lower CD-RISC scores and poorer cognitive function than healthy controls and the schizophrenia group scored lower than bipolar group on these measures as well. CD-RISC scores were positively correlated with all three cognitive measures in the entire sample but not within the diagnostic subgroups. Multiple regression analysis showed differences in CD-RISC between diagnostic groups were not mediated by differences in these three measures of neurocognition. Discussion: Schizophrenia and bipolar disorder are associated with impairments in both resilience and cognitive function but the impairment in resilience appears to be independent of deficits in cognitive function measured here and may reflect unmeasured dimensions of cognitive function, other impairments or environmental factors.
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影响因子：
7.6
作者：
BARON, RM;KENNY, DA
通讯作者：
KENNY, DA
DOI：
10.1080/10253890.2017.1286322
发表时间：
2017-01
期刊：
Stress (Amsterdam, Netherlands)
影响因子：
--
作者：
Shields GS;Moons WG;Slavich GM
通讯作者：
Slavich GM
影响因子：
7.4
作者：
Connor, KM;Davidson, JRT
通讯作者：
Davidson, JRT
DOI：
10.1080/01688638608401314
发表时间：
1986-06-01
影响因子：
2.2
作者：
CHELUNE, GJ;BAER, RA
通讯作者：
BAER, RA
影响因子：
4.5
作者：
Palmer BW;Martin AS;Depp CA;Glorioso DK;Jeste DV
通讯作者：
Jeste DV