Restoration of spinal cord injury: From endogenous repairing process to cellular therapy.
Restoration of spinal cord injury: From endogenous repairing process to cellular therapy.
复制标题
脊髓损伤的恢复：从内源性修复过程到细胞治疗
DOI：
10.3389/fncel.2022.1077441
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发表时间：
2022
影响因子：
5.3
通讯作者：
Liu, Shengwen
中科院分区：
文献类型：
--
作者：
Wu, Yaqi;Tang, Zhijian;Zhang, Jun;Wang, Yu;Liu, Shengwen
脊髓损伤(SCI)扰乱神经通路，影响感觉、运动和自主神经功能。目前尚无有效的治疗脊髓损伤的方法。大量的内源性细胞，包括星形胶质细胞、巨噬细胞/小胶质细胞和少突胶质细胞，参与了脊髓损伤后的组织学修复过程。通过干预脊髓损伤修复过程中的细胞，实现了脊髓损伤治疗的一些进展。然而，参与脊髓损伤修复的内源性细胞类型以及目前这些细胞在脊髓损伤治疗中面临的困难尚不清楚，其背后的机制也鲜为人知。为了更好地了解脊髓损伤，创造新的治疗策略，提高脊髓损伤修复的临床转化率，我们综合列举了参与脊髓损伤修复的内源性细胞，并总结了参与脊髓损伤修复的六种最常见的机制，包括限制炎症反应，保护备用脊髓，促进髓鞘形成，促进新生血管形成，产生神经营养因子，以及分化为神经/胶体细胞系。
Spinal cord injury (SCI) disrupts neurological pathways and impacts sensory, motor, and autonomic nerve function. There is no effective treatment for SCI currently. Numerous endogenous cells, including astrocytes, macrophages/microglia, and oligodendrocyte, are involved in the histological healing process following SCI. By interfering with cells during the SCI repair process, some advancements in the therapy of SCI have been realized. Nevertheless, the endogenous cell types engaged in SCI repair and the current difficulties these cells confront in the therapy of SCI are poorly defined, and the mechanisms underlying them are little understood. In order to better understand SCI and create new therapeutic strategies and enhance the clinical translation of SCI repair, we have comprehensively listed the endogenous cells involved in SCI repair and summarized the six most common mechanisms involved in SCI repair, including limiting the inflammatory response, protecting the spared spinal cord, enhancing myelination, facilitating neovascularization, producing neurotrophic factors, and differentiating into neural/colloidal cell lines.
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DOI：
10.1093/brain/aww039
发表时间：
2016-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Bartus K;Galino J;James ND;Hernandez-Miranda LR;Dawes JM;Fricker FR;Garratt AN;McMahon SB;Ramer MS;Birchmeier C;Bennett DL;Bradbury EJ
通讯作者：
Bradbury EJ
影响因子：
5.3
作者：
Beaumont, Eric;Onifer, Stephen M.;Magnuson, David S. K.
通讯作者：
Magnuson, David S. K.
影响因子：
2.4
作者：
Bearden, SE;Segal, SS
通讯作者：
Segal, SS
影响因子：
5.5
作者：
Berret, Emmanuelle;Kim, Sei Eun;Kim, Jun Hee
通讯作者：
Kim, Jun Hee
星形胶质细胞疤痕形成有助于中枢神经系统轴突再生。
影响因子：
64.8
作者：
Anderson MA;Burda JE;Ren Y;Ao Y;O'Shea TM;Kawaguchi R;Coppola G;Khakh BS;Deming TJ;Sofroniew MV
通讯作者：
Sofroniew MV